lbp-5 Fatty acid-binding protein homolog 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lbp-5
Official Full Name: Fatty acid-binding protein homolog 5
Primary source: WormBase:WBGene00002257
Locus tag: CELE_W02D3.7
See related: AllianceGenome:WB:WBGene00002257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables fatty acid binding activity. Predicted to be involved in fatty acid transport. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including arcade cell; hypodermis; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1G. Orthologous to several human genes including FABP12 (fatty acid binding protein 12); FABP4 (fatty acid binding protein 4); and FABP7 (fatty acid binding protein 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lbp-5 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003279.8 (6731267..6732276, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The disruption of the lbp-5 gene not only attenuated mitochondrial function but also enhanced aerobic glycolysis as indicated by lactate accumulation.
Title: Mutation of the lbp-5 gene alters metabolic output in Caenorhabditis elegans.
LBP-5 is required for stearic acid-induced transcription of NHR-49 target genes.
Title: Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02D3.7 (e-PCR)
- UniSTS:317226

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fatty acid-binding protein homolog 5

NP_491928.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6731267..6732276 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059527.6 → NP_491928.1 Fatty acid-binding protein homolog 5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01814

Conserved Domains (1) summary

pfam00061
Location:7 → 115

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family