med-1 GATA-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: med-1
Official Full Name: GATA-type domain-containing protein
Primary source: WormBase:WBGene00003180
Locus tag: CELE_T24D3.1
See related: AllianceGenome:WB:WBGene00003180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sequence-specific DNA binding activity. Involved in endodermal cell fate specification and pharynx development. Located in nucleus. Is expressed in several structures, including E; EMS; Ea; Eal; and Eala. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See med-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_003284.9 (12430609..12431133)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This suggests that normal adult intestine function requires robust embryonic activation of end-1,3 by MED-1,2.
Title: MED GATA factors promote robust development of the C. elegans endoderm.
no evidence for any significant maternal med-1/2 effect, after re-examination
Title: Neither maternal nor zygotic med-1/med-2 genes play a major role in specifying the Caenorhabditis elegans endoderm.
med transcripts accumulate both in the EMS cell and in the maternal germline in a SKN-1-dependent manner
Title: Maternal deployment of the embryonic SKN-1-->MED-1,2 cell specification pathway in C. elegans.
The major pathway(s) for endoderm specification in C. elegans must be independent of the med-1 and med-2 genes.
Title: Reevaluation of the role of the med-1 and med-2 genes in specifying the Caenorhabditis elegans endoderm.
The C blastomere in the oma-1 (zu405) mutant expresses a high level of this protein.
Title: A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T24D3.1 (e-PCR)
- UniSTS:317157

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in pharynx development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GATA-type domain-containing protein

NP_001366746.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12430609..12431133

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381117.1 → NP_001366746.1 GATA-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EF71

Conserved Domains (1) summary

smart00401
Location:109 → 160

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]