klf-3 Kruppel-like factor 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: klf-3
Official Full Name: Kruppel-like factor 3
Primary source: WormBase:WBGene00003480
Locus tag: CELE_F54H5.4
See related: AllianceGenome:WB:WBGene00003480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of lipid metabolic process. Predicted to be located in nucleus. Is expressed in germ line; hypodermis; intestine; and vulva. Orthologous to human KLF12 (KLF transcription factor 12); KLF2 (KLF transcription factor 2); and KLF8 (KLF transcription factor 8). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See klf-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (6618218..6622171)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that klf-3 is a hitherto unrecognized key regulator of fat metabolism in C. elegans, and is critical for maintaining normal fatty acid composition by regulating genes involved in a fatty acid desaturation pathway.
Title: Mutation in Caenorhabditis elegans Krüppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.
overexpression extends health and lifespan
Title: A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.
klf-3 regulates lipid metabolism, along with acs-1, acs-2, F08A8.1, and F08A8.2, by promoting FA beta-oxidation and, in parallel, may contribute to normal reproductive behavior and fecundity in C. elegans.
Title: Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans.
Genetic interactions between klf-3 and dsc-4, as well as vit-5 genes, suggest that klf-3 may have an important role in regulating lipid assembly and secretion.
Title: Regulation of lipoprotein assembly, secretion and fatty acid β-oxidation by Krüppel-like transcription factor, klf-3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54H5.4 (e-PCR)
- UniSTS:320085

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kruppel-like factor 3

NP_001022204.1

Partially confirmed by transcript evidence

NP_001022205.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6618218..6622171

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027034.6 → NP_001022205.1 Kruppel-like factor 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022205.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P91329, Q65ZG6

Conserved Domains (3) summary

COG5189
Location:215 → 314

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:235 → 254

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:276 → 301

zf-H2C2_2; Zinc-finger double domain
NM_001027033.2 → NP_001022204.1 Kruppel-like factor 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022204.1

Status: REVIEWED

UniProtKB/TrEMBL

P91329

Conserved Domains (2) summary

sd00017
Location:229 → 248

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:270 → 295

zf-H2C2_2; Zinc-finger double domain