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nxf-1 Nuclear RNA export factor 1 [ Caenorhabditis elegans ]

Gene ID: 191736, updated on 2-Nov-2024

Summary

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Official Symbol
nxf-1
Official Full Name
Nuclear RNA export factor 1
Primary source
WormBase:WBGene00003834
Locus tag
CELE_C15H11.3
See related
AllianceGenome:WB:WBGene00003834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Located in nuclear envelope; nucleolus; and nucleoplasm. Part of nuclear pore. Orthologous to human NXF1 (nuclear RNA export factor 1); NXF2 (nuclear RNA export factor 2); and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nxf-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (14411649..14415014, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene Cytochrome b-c1 complex subunit 10;Essential MCU regulator, mitochondrial Neighboring gene Nuclear RNA export factor 2 Neighboring gene SET domain-containing protein Neighboring gene DeHydrogenases, Short chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mRNA export in Caenorhabditis elegans is mediated by Ce-NXF-1, an ortholog of human TAP/NXF and Saccharomyces cerevisiae Mex67p. Tan W, et al. RNA, 2000 Dec. PMID 11142376, Free PMC Article
  2. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. MacMorris M, et al. RNA, 2003 Jul. PMID 12810918, Free PMC Article
  3. Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Kawano T, et al. Mech Dev, 2004 Jan. PMID 14706697
  4. The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold. Kerkow DE, et al. J Mol Biol, 2012 Jan 27. PMID 22123199, Free PMC Article
  5. Mutations in the NXF-1:NXT-1 mRNA export complex affect gene-expression driven by the hsp-16.41 promoter. Crawford MW, et al. MicroPubl Biol, 2023. PMID 37583452, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear RNA export factor 1
NP_001129880.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14411649..14415014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136408.4 → NP_001129880.1  Nuclear RNA export factor 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129880.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XVS7
    UniProtKB/TrEMBL
    B5BM32
    Conserved Domains (2) summary
    smart00804
    Location:550 → 608
    TAP_C; C-terminal domain of vertebrate Tap protein
    sd00035
    Location:184 → 226
    LRR_NTF; leucine-rich repeat [structural motif]
Nucleotide Protein
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