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old-1 Tyrosine-protein kinase receptor old-1 [ Caenorhabditis elegans ]

Gene ID: 191737, updated on 2-Nov-2024

Summary

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Official Symbol
old-1
Official Full Name
Tyrosine-protein kinase receptor old-1
Primary source
WormBase:WBGene00003862
Locus tag
CELE_C08H9.5
See related
AllianceGenome:WB:WBGene00003862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); leukemia (multiple); and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See old-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
9
Sequence:
Chromosome: II; NC_003280.10 (9866464..9868747, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene GH18 domain-containing protein;Glyco_18 domain-containing protein Neighboring gene pseudo Neighboring gene GH18 domain-containing protein Neighboring gene GH18 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. Murakami S, et al. Curr Biol, 1998 Sep 24. PMID 9768365
  2. Advantages and disadvantages of Caenorhabditis elegans for aging research. Johnson TE. Exp Gerontol, 2003 Nov-Dec. PMID 14698813
  3. Stress-inducible mechanisms of life-span extension in yeast, eubacteria and metazoans. Braeckman BP, et al. Trends Microbiol, 1999 Jul. PMID 10390634
  4. The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Murakami S, et al. Curr Biol, 2001 Oct 2. PMID 11591319
  5. A PAX6-regulated receptor tyrosine kinase pairs with a pseudokinase to activate immune defense upon oomycete recognition in Caenorhabditis elegans. Drury F, et al. Proc Natl Acad Sci U S A, 2023 Sep 26. PMID 37725647, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tyrosine-protein kinase receptor old-1
NP_496130.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9866464..9868747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063729.5 → NP_496130.2  Tyrosine-protein kinase receptor old-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496130.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17833
    Conserved Domains (2) summary
    smart00219
    Location:175 → 461
    TyrKc; Tyrosine kinase, catalytic domain
    cd00192
    Location:179 → 462
    PTKc; Catalytic domain of Protein Tyrosine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17833.3

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