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shw-3 BTB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191761, updated on 2-Nov-2024

Summary

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Official Symbol
shw-3
Official Full Name
BTB domain-containing protein
Primary source
WormBase:WBGene00004793
Locus tag
CELE_R186.5
See related
AllianceGenome:WB:WBGene00004793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables voltage-gated potassium channel activity. Involved in potassium ion transport. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Is expressed in head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 103 and progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1); KCNC2 (potassium voltage-gated channel subfamily C member 2); and KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See shw-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (12973261..12987161, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 39S ribosomal protein L33, mitochondrial Neighboring gene MoeA N-terminal and linker domain-containing protein Neighboring gene Pinin/SDK/MemA protein domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Auto-phosphorylation of a voltage-gated K+ channel controls non-associative learning. Cai SQ, et al. EMBO J, 2009 Jun 3. PMID 19387491, Free PMC Article
  2. An evolutionarily conserved mode of modulation of Shaw-like K⁺ channels. Cotella D, et al. FASEB J, 2013 Apr. PMID 23233530, Free PMC Article
  3. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
  4. A new gene-finding tool: using the Caenorhabditis elegans operons for identifying functional partner proteins in human cells. Eichmüller S, et al. J Biol Chem, 2004 Feb 20. PMID 14615488
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB domain-containing protein
NP_001355445.1
  • Confirmed by transcript evidence
NP_001366842.1
  • Confirmed by transcript evidence
NP_001368707.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12973261..12987161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380791.1 → NP_001366842.1  BTB domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEK7
    Conserved Domains (2) summary
    cl38908
    Location:4 → 115
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:236 → 423
    Ion_trans; Ion transport protein

  2. NM_001380790.1 → NP_001368707.1  BTB domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DVP6
    Conserved Domains (2) summary
    cl38908
    Location:22 → 133
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:245 → 441
    Ion_trans; Ion transport protein

  3. NM_001368471.3 → NP_001355445.1  BTB domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E007
    Conserved Domains (2) summary
    cl38908
    Location:25 → 136
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:257 → 444
    Ion_trans; Ion transport protein
Nucleotide Protein
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