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spo-11 DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11 [ Caenorhabditis elegans ]

Gene ID: 191771, updated on 2-Nov-2024

Summary

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Official Symbol
spo-11
Official Full Name
DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11
Primary source
WormBase:WBGene00004985
Locus tag
CELE_T05E11.4
See related
AllianceGenome:WB:WBGene00004985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in chromosome and nucleus. Predicted to be active in nuclear chromosome. Orthologous to human SPO11 (SPO11 initiator of meiotic double strand breaks). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spo-11 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11123133..11124862, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CLaudin-like in Caenorhabditis Neighboring gene Intramembrane protease 2 Neighboring gene Endoplasmin homolog Neighboring gene SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 Neighboring gene 3-hydroxyacyl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. Dernburg AF, et al. Cell, 1998 Aug 7. PMID 9708740
  2. Alternative induction of meiotic recombination from single-base lesions of DNA deaminases. Pauklin S, et al. Genetics, 2009 May. PMID 19237686, Free PMC Article
  3. Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans. Yeh HY, et al. Sci Rep, 2017 May 24. PMID 28539630, Free PMC Article
  4. To Break or Not To Break: Sex Chromosome Hemizygosity During Meiosis in Caenorhabditis. Van MV, et al. Genetics, 2016 Nov. PMID 27605052, Free PMC Article
  5. Modifying histones and initiating meiotic recombination; new answers to an old question. Maleki S, et al. Cell, 2004 Aug 20. PMID 15315752

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our studies highlight previously unknown functions of CRL4 in C. elegans meiosis and show that CUL-4 likely plays multiple roles in meiosis that are essential for maintaining genome integrity.
    Title: CRL4 regulates recombination and synaptonemal complex aggregation in the Caenorhabditis elegans germline.
  2. Data indicate that SPO-11 is monomeric and binds DNA, double-stranded DNA in particular.
    Title: Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic DNA double-strand break formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA double-strand break formation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic DNA double-strand break processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA topoisomerase (ATP-hydrolyzing);Meiotic recombination protein spo-11
NP_001294010.1
  • Confirmed by transcript evidence
NP_502081.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11123133..11124862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069680.5 → NP_502081.1  Meiotic recombination protein spo-11 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502081.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22236
    Conserved Domains (2) summary
    cd00223
    Location:196 → 358
    TOPRIM_TopoIIB_SPO; TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) ...
    pfam04406
    Location:91 → 151
    TP6A_N; Type IIB DNA topoisomerase

  2. NM_001307081.3 → NP_001294010.1  DNA topoisomerase (ATP-hydrolyzing) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294010.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AD57
    Conserved Domains (2) summary
    cd00223
    Location:149 → 311
    TOPRIM_TopoIIB_SPO; topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces ...
    pfam04406
    Location:45 → 103
    TP6A_N; Type IIB DNA topoisomerase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22236.1

Gene LinkOut

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