Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psme2provided by MGI
Official Full Name: proteasome (prosome, macropain) activator subunit 2 (PA28 beta)provided by MGI
Primary source: MGI:MGI:1096365
See related: Ensembl:ENSMUSG00000079197 AllianceGenome:MGI:1096365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PA28b
Summary: Contributes to endopeptidase activator activity. Acts upstream of or within antigen processing and presentation of exogenous antigen. Predicted to be part of proteasome activator complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and pancreas. Orthologous to human PSME2 (proteasome activator subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 78.6), duodenum adult (RPKM 27.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55824897..55828558, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55587440..55591101, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy.
Title: PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.
Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species.
Title: The Mammalian Proteasome Activator PA28 Forms an Asymmetric α(4)β(3) Complex.
Increased PA28B expression is associated with viral myocarditis.
Title: PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection.
Nrf2-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.
Title: Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.
demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides
Title: PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.
PA28-associated proteasome preferentially digested within epitopic sequences of K(d), although correct C-terminal flankings were removed
Title: Allele-selective effect of PA28 in MHC class I antigen processing.
An alternative splice pattern of the Psme2 (PA28b) gene, which encodes the beta subunit of the proteasome activator PA28, is characterized.
Title: Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes.
the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90
Title: Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71322 (e-PCR)
- UniSTS:84774

MARC_4677-4678:996679594:1 (e-PCR)
- UniSTS:269415

UniSTS:144282 (e-PCR)
- UniSTS:144282

Psme2 (e-PCR), detects polymorphism
- UniSTS:144282

AI788882 (e-PCR)
- UniSTS:180659

RH129915 (e-PCR)
- UniSTS:213203

Psme2 (e-PCR), detects polymorphism
- UniSTS:256483

RH124942 (e-PCR)
- UniSTS:161764

UniSTS:256484 (e-PCR)
- UniSTS:256484

Psme2 (e-PCR), detects polymorphism
- UniSTS:256484

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation of exogenous antigen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome activator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome activator complex subunit 2

Names: 11S regulator complex subunit beta; PA28beta; REG-beta; activator of multicatalytic protease subunit 2; protease (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) 28 subunit, beta; proteasome activator 28 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029855.1 → NP_001025026.1 proteasome activator complex subunit 2 isoform 2

See identical proteins and their annotated locations for NP_001025026.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate transcription initiation site and uses a distinct start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AA216967, AA267668, AK012344, BB869062

Consensus CDS

CCDS49495.1

UniProtKB/TrEMBL

G3X9V0

Related

ENSMUSP00000107009.4, ENSMUST00000111378.10

Conserved Domains (2) summary

pfam02251
Location:9 → 57

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:88 → 229

PA28_beta; Proteasome activator pa28 beta subunit
NM_011190.3 → NP_035320.1 proteasome activator complex subunit 2 isoform 1

See identical proteins and their annotated locations for NP_035320.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA216967, AK012344, BU563130, BY134400, BY498670, CA536627

Consensus CDS

CCDS49494.1

UniProtKB/Swiss-Prot

O35562, P97372

UniProtKB/TrEMBL

A0A1G5SJA5, Q5SVP3

Related

ENSMUSP00000123798.2, ENSMUST00000161807.8

Conserved Domains (2) summary

pfam02251
Location:12 → 66

PA28_alpha; Proteasome activator pa28 alpha subunit

pfam02252
Location:94 → 235

PA28_beta; Proteasome activator pa28 beta subunit