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Pipox pipecolic acid oxidase [ Mus musculus (house mouse) ]

Gene ID: 19193, updated on 2-Nov-2024

Summary

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Official Symbol
Pipoxprovided by MGI
Official Full Name
pipecolic acid oxidaseprovided by MGI
Primary source
MGI:MGI:1197006
See related
Ensembl:ENSMUSG00000017453 AllianceGenome:MGI:1197006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pso; LPIPOX
Summary
Predicted to enable L-pipecolate oxidase activity and sarcosine oxidase activity. Predicted to be involved in L-lysine catabolic process to acetyl-CoA via L-pipecolate. Located in peroxisome. Is expressed in alimentary system; liver; nervous system; and urinary system. Orthologous to human PIPOX (pipecolic acid and sarcosine oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney adult (RPKM 95.8), liver adult (RPKM 89.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Pipox in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77771440..77784698, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77880614..77893872, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin XVIIIA Neighboring gene STARR-seq mESC enhancer starr_30068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77605328-77605830 Neighboring gene STARR-seq mESC enhancer starr_30070 Neighboring gene predicted gene 10277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77616184-77616337 Neighboring gene predicted gene, 36875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77700892-77701111 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77701174-77701361 Neighboring gene STARR-seq mESC enhancer starr_30074 Neighboring gene predicted gene, 29932 Neighboring gene STARR-seq mESC enhancer starr_30076 Neighboring gene VISTA enhancer mm981 Neighboring gene predicted gene, 29979 Neighboring gene predicted gene 11190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1. Herbst R, et al. Genomics, 1997 Dec 15. PMID 9441754
  2. L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. Dodt G, et al. Biochem J, 2000 Feb 1. PMID 10642506, Free PMC Article
  3. Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma. Mohammed Y, et al. NPJ Syst Biol Appl, 2021 May 28. PMID 34050187, Free PMC Article
  4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-pipecolate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-pipecolate oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-pipecolate oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables sarcosine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sarcosine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables sarcosine oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine catabolic process to acetyl-CoA via L-pipecolate ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal sarcosine oxidase
Names
L-pipecolate oxidase
L-pipecolic acid oxidase
NP_032978.2
XP_011247109.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008952.2 → NP_032978.2  peroxisomal sarcosine oxidase

    See identical proteins and their annotated locations for NP_032978.2

    Status: VALIDATED

    Source sequence(s)
    AK149488, BB561815, BY708439, U94700
    Consensus CDS
    CCDS25086.1
    UniProtKB/Swiss-Prot
    O55223, Q9D826
    UniProtKB/TrEMBL
    Q3UEJ8
    Related
    ENSMUSP00000017597.5, ENSMUST00000017597.5
    Conserved Domains (2) summary
    TIGR01377
    Location:8 → 388
    soxA_mon; sarcosine oxidase, monomeric form
    pfam13450
    Location:12 → 38
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77771440..77784698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248807.1 → XP_011247109.1  peroxisomal sarcosine oxidase isoform X1

    Conserved Domains (1) summary
    TIGR01377
    Location:8 → 374
    soxA_mon; sarcosine oxidase, monomeric form
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D826.1 GenPept UniProtKB/Swiss-Prot:Q9D826

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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