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srp-8 Serpin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191960, updated on 2-Nov-2024

Summary

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Official Symbol
srp-8
Official Full Name
Serpin domain-containing protein
Primary source
WormBase:WBGene00005649
Locus tag
CELE_F20D6.3
See related
AllianceGenome:WB:WBGene00005649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB10 (serpin family B member 10); and SERPINB11 (serpin family B member 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See srp-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (8183684..8185879)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Histone H2A/H2B/H3 domain-containing protein Neighboring gene Serpin domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Luke CJ, et al. Front Biosci, 2006 Jan 1. PMID 16146754
  2. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. Pak SC, et al. J Biol Chem, 2004 Apr 9. PMID 14739286
  3. Quantifying Food Intake in Caenorhabditis elegans by Measuring Bacterial Clearance. Clark C, et al. J Vis Exp, 2024 Feb 23. PMID 38465935
  4. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serpin domain-containing protein
NP_001309497.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8183684..8185879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322578.3 → NP_001309497.1  Serpin domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19651
    Conserved Domains (1) summary
    cd19581
    Location:14 → 370
    serpinL_nematode; serpin family L, serpin family proteins from nematodes
Nucleotide Protein
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Gene LinkOut

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