Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pstpip1provided by MGI
Official Full Name: proline-serine-threonine phosphatase-interacting protein 1provided by MGI
Primary source: MGI:MGI:1321396
See related: Ensembl:ENSMUSG00000032322 AllianceGenome:MGI:1321396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: def-2; CD2BP1
Summary: Enables actin binding activity and protein phosphatase binding activity. Predicted to be involved in actin filament polymerization. Located in actomyosin contractile ring; cleavage furrow; and stress fiber. Is expressed in several structures, including genitourinary system; liver; musculature; pancreas; and spleen. Human ortholog(s) of this gene implicated in PAPA syndrome. Orthologous to human PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in thymus adult (RPKM 36.1), spleen adult (RPKM 16.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 30.13 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (55985729..56036174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (56078445..56128890)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a new PSTPIP1/PTPN6/SHIP1/2-dependent negative feedback mechanism that counterbalances Src and PI(3,4,5)P3 signalling to control osteoclast cell polarity and activity during bone resorption
Title: BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts.
analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins
Title: Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration
Title: The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.
the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL
Title: Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokinesis	IC Inferred by Curator more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in uropod	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proline-serine-threonine phosphatase-interacting protein 1

Names: PEST phosphatase-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409150.1 → NP_001396079.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409151.1 → NP_001396080.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409152.1 → NP_001396081.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409153.1 → NP_001396082.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409154.1 → NP_001396083.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409155.1 → NP_001396084.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409156.1 → NP_001396085.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409157.1 → NP_001396086.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 9

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409158.1 → NP_001396087.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 10

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409159.1 → NP_001396088.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409160.1 → NP_001396089.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC158999
NM_001409161.1 → NP_001396090.1 proline-serine-threonine phosphatase-interacting protein 1 isoform 11

Status: VALIDATED

Source sequence(s)

AC158999
NM_011193.3 → NP_035323.2 proline-serine-threonine phosphatase-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_035323.2

Status: VALIDATED

Source sequence(s)

AC158999

Consensus CDS

CCDS40645.1

UniProtKB/Swiss-Prot

P97814, Q4V9R4

UniProtKB/TrEMBL

A0A0R4J0P5

Related

ENSMUSP00000055823.8, ENSMUST00000059206.8

Conserved Domains (2) summary

cd11824
Location:362 → 414

SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

cl12013
Location:16 → 257

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

55985729..56036174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242677.3 → XP_011240979.1 proline-serine-threonine phosphatase-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

P97814, Q4V9R4

Conserved Domains (2) summary

cd11824
Location:351 → 403

SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

cl12013
Location:5 → 246

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006510865.3 → XP_006510928.1 proline-serine-threonine phosphatase-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

P97814, Q4V9R4

Conserved Domains (2) summary

cd07671
Location:35 → 276

F-BAR_PSTPIP1; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1

cd11824
Location:381 → 433

SH3_PSTPIP1; Src homology 3 domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1