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Bspry B-box and SPRY domain containing [ Mus musculus (house mouse) ]

Gene ID: 192120, updated on 2-Nov-2024

Summary

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Official Symbol
Bspryprovided by MGI
Official Full Name
B-box and SPRY domain containingprovided by MGI
Primary source
MGI:MGI:2177191
See related
Ensembl:ENSMUSG00000028392 AllianceGenome:MGI:2177191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell leading edge and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including cornea epithelium; genitourinary system; gut; nose; and salivary gland primordium. Orthologous to human BSPRY (B-box and SPRY domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 181.8), colon adult (RPKM 118.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Bspry in Genome Data Viewer
Location:
4 B3; 4 33.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62398248..62415537)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62480011..62497300)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 183 Neighboring gene predicted gene, 30589 Neighboring gene WD repeat domain 31 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 3 Neighboring gene aminolevulinate, delta-, dehydratase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B-box and SPRY domain containing protein (BSPRY) is associated with the maintenance of mouse embryonic stem cell pluripotency and early embryonic development. Ikeda M, et al. J Reprod Dev, 2012. PMID 22972184
  2. CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases. Li X, et al. J Cell Mol Med, 2020 Apr. PMID 32181567, Free PMC Article
  3. BSPRY, a novel protein of the Ro-Ret family. Schenker T, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978534
  4. Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity. van de Graaf SF, et al. J Am Soc Nephrol, 2006 Jan. PMID 16380433
  5. Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. Birkenfeld J, et al. Biochem Biophys Res Commun, 2003 Mar 14. PMID 12615066

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases.
    Title: CXCR4-SF1 bifunctional adipose-derived stem cells benefit for the treatment of Leydig cell dysfunction-related diseases.
  2. associated with both embryonic stem cell pluripotency and early embryonic development
    Title: B-box and SPRY domain containing protein (BSPRY) is associated with the maintenance of mouse embryonic stem cell pluripotency and early embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables vitamin D binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
B box and SPRY domain-containing protein
Names
zetin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368623.1 → NP_001355552.1  B box and SPRY domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732594
    Consensus CDS
    CCDS89757.1
    UniProtKB/Swiss-Prot
    Q3TU74, Q80YW5, Q8BZF0, Q99KV7, Q9ER70
    Related
    ENSMUSP00000103073.4, ENSMUST00000107449.4
    Conserved Domains (1) summary
    cl02614
    Location:282 → 449
    SPRY; SPRY domain

  2. NM_001429886.1 → NP_001416815.1  B box and SPRY domain-containing protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL732594

  3. NM_138653.2 → NP_619594.1  B box and SPRY domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_619594.1

    Status: VALIDATED

    Source sequence(s)
    AL732594
    Consensus CDS
    CCDS18241.1
    UniProtKB/TrEMBL
    B2RT02
    Related
    ENSMUSP00000030088.6, ENSMUST00000030088.12
    Conserved Domains (1) summary
    cl02614
    Location:282 → 449
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62398248..62415537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537676.4 → XP_006537739.2  B box and SPRY domain-containing protein isoform X1

    Conserved Domains (1) summary
    cl00034
    Location:69 → 111
    Bbox_SF; B-box-type zinc finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YW5.1 GenPept UniProtKB/Swiss-Prot:Q80YW5

Gene LinkOut

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