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Ufsp2 UFM1-specific peptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 192169, updated on 2-Nov-2024

Summary

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Official Symbol
Ufsp2provided by MGI
Official Full Name
UFM1-specific peptidase 2provided by MGI
Primary source
MGI:MGI:1913679
See related
Ensembl:ENSMUSG00000031634 AllianceGenome:MGI:1913679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810047C23Rik
Summary
Enables deUFMylase activity. Involved in regulation of type II interferon production. Located in endoplasmic reticulum and nucleus. Is expressed in liver; orbito-sphenoid; pancreas epithelium; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 16.2), bladder adult (RPKM 14.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ufsp2 in Genome Data Viewer
Location:
8 B1.1; 8 25.96 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46428551..46449995)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45975515..45996958)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 3 Neighboring gene STARR-seq mESC enhancer starr_21375 Neighboring gene STARR-positive B cell enhancer mm9_chr8:47020100-47020401 Neighboring gene coiled-coil domain containing 110 Neighboring gene cilia and flagella associated protein 96 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47060555-47060664 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene ankyrin repeat domain 37 Neighboring gene Lrp2 binding protein Neighboring gene sorting nexin 25 Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. Ha BH, et al. J Biol Chem, 2011 Mar 25. PMID 21228277, Free PMC Article
  2. Structural basis for Ufm1 processing by UfSP1. Ha BH, et al. J Biol Chem, 2008 May 23. PMID 18321862
  3. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Balce DR, et al. Proc Natl Acad Sci U S A, 2021 Jan 5. PMID 33372156, Free PMC Article
  4. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. Kang SH, et al. J Biol Chem, 2007 Feb 23. PMID 17182609
  5. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Yang R, et al. Development, 2019 Jan 25. PMID 30635284

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of ubiquitin-fold modifier 1-specific protease UfSP2.
    Title: Structure of ubiquitin-fold modifier 1-specific protease UfSP2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC7482

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deUFMylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deUFMylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deUFMylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables deUFMylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular estrogen receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ufm1-specific protease 2
NP_619609.1
XP_006509372.1
XP_017168107.1
XP_036009725.1
XP_036009726.1
XP_036009727.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138668.2 → NP_619609.1  ufm1-specific protease 2

    See identical proteins and their annotated locations for NP_619609.1

    Status: VALIDATED

    Source sequence(s)
    AC114558, AK075795, AK078309
    Consensus CDS
    CCDS22284.1
    UniProtKB/Swiss-Prot
    Q8C5I0, Q99K23
    Related
    ENSMUSP00000034051.7, ENSMUST00000034051.7
    Conserved Domains (1) summary
    pfam07910
    Location:272 → 453
    Peptidase_C78; Peptidase family C78

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46428551..46449995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312618.3 → XP_017168107.1  ufm1-specific protease 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5I0, Q99K23
    Conserved Domains (1) summary
    pfam07910
    Location:272 → 453
    Peptidase_C78; Peptidase family C78

  2. XM_036153833.1 → XP_036009726.1  ufm1-specific protease 2 isoform X3

    Conserved Domains (1) summary
    pfam07910
    Location:93 → 274
    Peptidase_C78; Peptidase family C78

  3. XM_006509309.3 → XP_006509372.1  ufm1-specific protease 2 isoform X2

    Conserved Domains (1) summary
    pfam07910
    Location:161 → 342
    Peptidase_C78; Peptidase family C78

  4. XM_036153834.1 → XP_036009727.1  ufm1-specific protease 2 isoform X3

    Conserved Domains (1) summary
    pfam07910
    Location:93 → 274
    Peptidase_C78; Peptidase family C78

  5. XM_036153832.1 → XP_036009725.1  ufm1-specific protease 2 isoform X2

    Conserved Domains (1) summary
    pfam07910
    Location:161 → 342
    Peptidase_C78; Peptidase family C78
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99K23.1 GenPept UniProtKB/Swiss-Prot:Q99K23

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