Lrrc4 leucine rich repeat containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc4provided by MGI
Official Full Name: leucine rich repeat containing 4provided by MGI
Primary source: MGI:MGI:2182081
See related: Ensembl:ENSMUSG00000049939 AllianceGenome:MGI:2182081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NGL2; MBAG1; NGL-2; NLG-2; Nag14
Summary: Involved in modulation of chemical synaptic transmission. Acts upstream of or within excitatory synapse assembly and postsynaptic density protein 95 clustering. Located in dendritic spine; excitatory synapse; and postsynaptic membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including branchial arch; central nervous system; metanephros; sensory organ; and vibrissa. Orthologous to human LRRC4 (leucine rich repeat containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.05 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (28828125..28831746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (28828126..28831747, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.
Title: LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.
Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide.
Title: Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide.
Mice lacking NGL-2 (Lrrc4(-/-) mice) show suppressed N-Methyl-D-aspartate receptor (NMDAR)-dependent synaptic plasticity in the hippocampus. NGL-2 associates with NMDARs through both PSD-95-dependent and -independent mechanisms.
Title: NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation.
NGL2 protein (NGL2) promotes the formation, maintenance, and restoration of synapses in the developing and mature retina.
Title: Synapse maintenance and restoration in the retina by NGL2.
our results identify NGL-2 as a central component of pathway-specific development in the outer retina.
Title: NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina.
These results demonstrate that NGL-2 is critical for pathway-specific synapse development and functional integration of distinct inputs.
Title: NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons.
Promotes neurite extension of hippocampal neurons, and induces differentiation of glioblastoma U251 cells into astrocyte-like cells.
Title: Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation.
LRRC4 may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system.
Title: Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily.
Together, these findings provide clues to the function of LRRC4 as a negative regulator of cell growth and underscore a link between the above-mentioned cyclins, cyclin-associated molecules and tumorigenicity.
Title: Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:4585141 (e-PCR)
- UniSTS:4885

Lrrc4 (e-PCR), detects polymorphism
- UniSTS:525557

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in excitatory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density protein 95 clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuron spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing protein 4

Names: LIBG-like protein; LRRC4-like protein; brain tumor-associated protein MBAG1; netrin-G2 ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138682.2 → NP_619623.2 leucine-rich repeat-containing protein 4 precursor

See identical proteins and their annotated locations for NP_619623.2

Status: VALIDATED

Source sequence(s)

AC068662, BE945283

Consensus CDS

CCDS39448.1

UniProtKB/Swiss-Prot

Q149E5, Q8VI35, Q99PH1

UniProtKB/TrEMBL

Q149E6

Related

ENSMUSP00000062158.6, ENSMUST00000062304.7

Conserved Domains (7) summary

smart00013
Location:45 → 78

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:299 → 350

LRRCT; Leucine rich repeat C-terminal domain

smart00410
Location:358 → 440

IG_like; Immunoglobulin like

cd00116
Location:91 → 304

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:76 → 99

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:74 → 132

LRR_8; Leucine rich repeat

cl11960
Location:369 → 440

Ig; Immunoglobulin domain