U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fap fibroblast activation protein, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 192203, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Fapprovided by RGD
Official Full Name
fibroblast activation protein, alphaprovided by RGD
Primary source
RGD:621253
See related
Ensembl:ENSRNOG00000005679 AllianceGenome:RGD:621253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including integrin binding activity; peptidase activity; and protein homodimerization activity. Predicted to be involved in several processes, including melanocyte apoptotic process; melanocyte proliferation; and negative regulation of cell proliferation involved in contact inhibition. Predicted to be located in several cellular components, including basal part of cell; cell surface; and lamellipodium. Predicted to be part of peptidase complex. Predicted to be active in plasma membrane. Orthologous to human FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 83.3), Uterus (RPKM 61.1) and 5 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fap in Genome Data Viewer
Location:
3q21
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67547398..67616271, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (47138823..47207671, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (48467781..48536242, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101554 Neighboring gene uncharacterized LOC103691814 Neighboring gene glucagon Neighboring gene interferon induced with helicase C domain 1 Neighboring gene SHOC2 leucine-rich repeat scaffold protein, pseudogene 1 Neighboring gene grancalcin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of fibroblast activation proteins in corneal stromal neovascularization. Wang T, et al. Curr Eye Res, 2009 Feb. PMID 19219682
  2. Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers. Kilvaer TK, et al. PLoS One, 2015. PMID 26252379, Free PMC Article
  3. FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. Ramirez-Montagut T, et al. Oncogene, 2004 Jul 15. PMID 15133496
  4. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. Piñeiro-Sánchez ML, et al. J Biol Chem, 1997 Mar 21. PMID 9065413
  5. Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer. Kilvaer TK, et al. PLoS One, 2018. PMID 29415055, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in melanocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in melanocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell proliferation involved in contact inhibition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of collagen catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in basal part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
  
part_of peptidase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
prolyl endopeptidase FAP
Names
seprase
NP_620205.1
XP_038960153.1
XP_038960154.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138850.1 → NP_620205.1  prolyl endopeptidase FAP

    See identical proteins and their annotated locations for NP_620205.1

    Status: PROVISIONAL

    Source sequence(s)
    AF493782
    UniProtKB/TrEMBL
    A0A8I6G286, A0A9K3Y732, F1LMH7, Q8R492
    Related
    ENSRNOP00000008148.7, ENSRNOT00000008148.7
    Conserved Domains (2) summary
    pfam00326
    Location:553 → 760
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:106 → 473
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    67547398..67616271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104226.2 → XP_038960154.1  prolyl endopeptidase FAP isoform X2

    UniProtKB/TrEMBL
    A0A8I6G286
    Conserved Domains (2) summary
    pfam00326
    Location:553 → 702
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:106 → 473
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. XM_039104225.2 → XP_038960153.1  prolyl endopeptidase FAP isoform X1

    UniProtKB/TrEMBL
    A0A8I6G286
    Conserved Domains (2) summary
    pfam00326
    Location:553 → 728
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:106 → 473
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools