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Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192258, updated on 2-Nov-2024

Summary

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Official Symbol
Gabrr3provided by RGD
Official Full Name
gamma-aminobutyric acid type A receptor subunit rho3provided by RGD
Primary source
RGD:621564
See related
EnsemblRapid:ENSRNOG00000001679 AllianceGenome:RGD:621564
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GABA-A receptor activity; GABA-gated chloride ion channel activity; and protein domain specific binding activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic membrane. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 5.8), Thymus (RPKM 4.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gabrr3 in Genome Data Viewer
Location:
11q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54372017..54424466, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40902812..40955263, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43046987..43099754, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene olfactory receptor family 5 subfamily AC member 25 Neighboring gene olfactory receptor family 5 subfamily AC member 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. Vien J, et al. Br J Pharmacol, 2002 Feb. PMID 11861315, Free PMC Article
  2. Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Ogurusu T, et al. Biochim Biophys Acta, 1996 Feb 7. PMID 8605242
  3. Expression of GABArho subunits during rat cerebellum development. Mejía C, et al. Neurosci Lett, 2008 Feb 13. PMID 18201822
  4. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, et al. J Biol Chem, 2003 Feb 21. PMID 12431995
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA-A receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-A receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GABA-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit rho-3
Names
GABA receptor rho-3 subunit
GABA(A) receptor subunit rho-3
GABA(C) receptor
GABAAR subunit rho-3
gamma-aminobutyric acid (GABA) A receptor, rho 3
gamma-aminobutyric acid (GABA) receptor, rho 3
gamma-aminobutyric acid type A receptor rho3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138897.2 → NP_620252.1  gamma-aminobutyric acid receptor subunit rho-3 precursor

    See identical proteins and their annotated locations for NP_620252.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P50573
    UniProtKB/TrEMBL
    A6IQJ1
    Related
    ENSRNOP00000002281.4, ENSRNOT00000002281.6
    Conserved Domains (3) summary
    TIGR00860
    Location:58 → 463
    LIC; Cation transporter family protein
    cd03558
    Location:181 → 195
    LGIC_ECD; Cys-loop [structural motif]
    cl28912
    Location:79 → 264
    LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    54372017..54424466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50573.1 GenPept UniProtKB/Swiss-Prot:P50573

Gene LinkOut

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