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Ppp1r3b protein phosphatase 1, regulatory subunit 3B [ Rattus norvegicus (Norway rat) ]

Gene ID: 192280, updated on 14-Nov-2024

Summary

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Official Symbol
Ppp1r3bprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 3Bprovided by RGD
Primary source
RGD:621600
See related
EnsemblRapid:ENSRNOG00000011474 AllianceGenome:RGD:621600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables [phosphorylase] phosphatase activity; enzyme binding activity; and protein phosphatase regulator activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 440.7), Thymus (RPKM 128.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r3b in Genome Data Viewer
Location:
16q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (63533318..63545683, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (56830011..56842395, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (60415192..60427498, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553369 Neighboring gene uncharacterized LOC134482394 Neighboring gene uncharacterized LOC120097474 Neighboring gene uncharacterized LOC134482397 Neighboring gene ribosomal protein L21, pseudogene 23 Neighboring gene uncharacterized LOC134482395

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1. Doherty MJ, et al. FEBS Lett, 1995 Nov 20. PMID 7498521
  2. Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes. Zibrova D, et al. Biochem J, 2008 Jun 1. PMID 18298402
  3. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, et al. Biochem J, 2001 Dec 1. PMID 11716774, Free PMC Article
  4. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead G, et al. FEBS Lett, 1995 Apr 3. PMID 7720853
  5. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, et al. FEBS J, 2005 Mar. PMID 15752363

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
    Title: Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [phosphorylase] phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycogen biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of glycogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in glycogen granule IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 3B
Names
33 kDa glycogen-binding protein
PP1 subunit R4
R4
hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
protein phosphatase 1 (GL-subunit)
protein phosphatase 1 regulatory subunit 4
protein phosphatase 1 subunit GL
protein phosphatase 1, regulatory (inhibitor) subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001434432.1 → NP_001421361.1  protein phosphatase 1 regulatory subunit 3B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  2. NM_001434433.1 → NP_001421362.1  protein phosphatase 1 regulatory subunit 3B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  3. NM_138912.3 → NP_620267.2  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_620267.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    Q63759, Q6IN01
    UniProtKB/TrEMBL
    A6IVM9
    Related
    ENSRNOP00000108106.1, ENSRNOT00000148975.1
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    63533318..63545683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253216.5 → XP_006253278.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    UniProtKB/Swiss-Prot
    Q63759, Q6IN01
    UniProtKB/TrEMBL
    A6IVM9
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

  2. XM_006253215.4 → XP_006253277.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    UniProtKB/Swiss-Prot
    Q63759, Q6IN01
    UniProtKB/TrEMBL
    A6IVM9
    Related
    ENSRNOP00000042713.2, ENSRNOT00000051720.4
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

RNA

  1. XR_010058276.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IN01.1 GenPept UniProtKB/Swiss-Prot:Q6IN01

Gene LinkOut

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