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Fnbp1 formin binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192348, updated on 2-Nov-2024

Summary

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Symbol
Fnbp1provided by RGD
Full Name
formin binding protein 1provided by RGD
Primary source
RGD:621350
See related
EnsemblRapid:ENSRNOG00000008258 AllianceGenome:RGD:621350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Involved in nervous system development. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human FNBP1 (formin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 85.2), Thymus (RPKM 52.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fnbp1 in Genome Data Viewer
Location:
3p12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34706814..34826770, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14309067..14424378, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9865657..9936333, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 78 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene U12 minor spliceosomal RNA Neighboring gene G protein-coupled receptor 107 Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial-like Neighboring gene neuronal calcium sensor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vivo function of Rnd2 in the development of neocortical pyramidal neurons. Nakamura K, et al. Neurosci Res, 2006 Feb. PMID 16303198
  2. The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons. Wakita Y, et al. J Biol Chem, 2011 Sep 16. PMID 21768103, Free PMC Article
  3. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. Fujita H, et al. J Biol Chem, 2002 Nov 22. PMID 12244061
  4. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Shimada A, et al. Cell, 2007 May 18. PMID 17512409
  5. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart F, et al. Mol Vis, 2005 Dec 9. PMID 16357825

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics.
    Title: The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons.
  2. Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation.
    Title: Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching.
  3. Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons
    Title: In vivo function of Rnd2 in the development of neocortical pyramidal neurons.
  4. functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP.
    Title: Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin-binding protein 1
Names
formin-binding protein 1-like
formin-binding protein 17
rapostlin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393677.1 → NP_001380606.1  formin-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q75UE2, Q75UE3, Q75UE4, Q75UE5, Q75UE6, Q8R511
    UniProtKB/TrEMBL
    Z4YNH5
    Related
    ENSRNOP00000092158.2, ENSRNOT00000110957.2
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:406 → 482
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:552 → 608
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

  2. NM_001393678.1 → NP_001380607.1  formin-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    Z4YNH5
    Related
    ENSRNOP00000049838.6, ENSRNOT00000042798.8
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:401 → 477
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cl17036
    Location:547 → 603
    SH3; Src Homology 3 domain superfamily

  3. NM_001393679.1 → NP_001380608.1  formin-binding protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A8B9
    Conserved Domains (3) summary
    cl00087
    Location:377 → 453
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl12013
    Location:5 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:523 → 579
    SH3; Src Homology 3 domain superfamily

  4. NM_001393680.1 → NP_001380609.1  formin-binding protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A8B9
    Conserved Domains (3) summary
    cl00087
    Location:372 → 448
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl12013
    Location:5 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:518 → 574
    SH3; Src Homology 3 domain superfamily

  5. NM_001393681.1 → NP_001380610.1  formin-binding protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A8B9
    Conserved Domains (3) summary
    cl00087
    Location:345 → 421
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl12013
    Location:5 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:491 → 547
    SH3; Src Homology 3 domain superfamily

  6. NM_001393682.1 → NP_001380611.1  formin-binding protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6A8B9
    Conserved Domains (3) summary
    cl00087
    Location:340 → 416
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl12013
    Location:5 → 257
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:486 → 542
    SH3; Src Homology 3 domain superfamily

  7. NM_138914.2 → NP_620269.1  formin-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_620269.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    Z4YNH5
    Conserved Domains (3) summary
    cd07676
    Location:5 → 257
    F-BAR_FBP17; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 17
    cd11629
    Location:406 → 482
    HR1_FBP17; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Formin Binding Protein 17
    cd12071
    Location:552 → 608
    SH3_FBP17; Src Homology 3 domain of Formin Binding Protein 17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    34706814..34826770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283065.1 → XP_063139135.1  formin-binding protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AH08

  2. XM_063283060.1 → XP_063139130.1  formin-binding protein 1 isoform X3

  3. XM_063283064.1 → XP_063139134.1  formin-binding protein 1 isoform X7

  4. XM_063283061.1 → XP_063139131.1  formin-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GFT9
    Related
    ENSRNOP00000088096.1, ENSRNOT00000106082.2

  5. XM_063283070.1 → XP_063139140.1  formin-binding protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I6AD72
    Related
    ENSRNOP00000091155.1, ENSRNOT00000096687.2

  6. XM_063283071.1 → XP_063139141.1  formin-binding protein 1 isoform X14

  7. XM_063283068.1 → XP_063139138.1  formin-binding protein 1 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZUF2
    Related
    ENSRNOP00000082158.2, ENSRNOT00000119242.2

  8. XM_063283067.1 → XP_063139137.1  formin-binding protein 1 isoform X10

  9. XM_063283058.1 → XP_063139128.1  formin-binding protein 1 isoform X1

  10. XM_063283069.1 → XP_063139139.1  formin-binding protein 1 isoform X12

  11. XM_063283066.1 → XP_063139136.1  formin-binding protein 1 isoform X9

  12. XM_063283063.1 → XP_063139133.1  formin-binding protein 1 isoform X6

  13. XM_063283062.1 → XP_063139132.1  formin-binding protein 1 isoform X5

  14. XM_063283059.1 → XP_063139129.1  formin-binding protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R511.2 GenPept UniProtKB/Swiss-Prot:Q8R511

Gene LinkOut

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