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Rassf3 Ras association (RalGDS/AF-6) domain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 192678, updated on 28-Oct-2024

Summary

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Official Symbol
Rassf3provided by MGI
Official Full Name
Ras association (RalGDS/AF-6) domain family member 3provided by MGI
Primary source
MGI:MGI:2179722
See related
Ensembl:ENSMUSG00000025795 AllianceGenome:MGI:2179722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in embryo mesenchyme and tongue. Orthologous to human RASSF3 (Ras association domain family member 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 43.3), lung adult (RPKM 33.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rassf3 in Genome Data Viewer
Location:
10 D2; 10 69.7 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121246255..121312220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121410350..121476250, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9808 Neighboring gene STARR-positive B cell enhancer ABC_E11462 Neighboring gene STARR-positive B cell enhancer ABC_E9809 Neighboring gene glucosamine (N-acetyl)-6-sulfatase Neighboring gene mitochondrial ribosomal protein S11 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5194 Neighboring gene predicted gene, 53638 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:120913883-120914036 Neighboring gene STARR-positive B cell enhancer ABC_E5195 Neighboring gene predicted gene, 40787 Neighboring gene STARR-positive B cell enhancer ABC_E11463 Neighboring gene predicted gene, 46204

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Tommasi S, et al. Oncogene, 2002 Apr 18. PMID 11965544
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 3
Names
Ras association (RalGDS/AF-6) domain family 3
Ras association domain family 3
novel ras effector 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418941.1 → NP_001405870.1  ras association domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140264

  2. NM_138956.4 → NP_620406.1  ras association domain-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_620406.1

    Status: VALIDATED

    Source sequence(s)
    AC140264
    Consensus CDS
    CCDS24211.1
    UniProtKB/Swiss-Prot
    Q3TJ17, Q99P51
    Related
    ENSMUSP00000026902.8, ENSMUST00000026902.9
    Conserved Domains (2) summary
    cd01778
    Location:78 → 182
    RASSF1_RA; Ubiquitin-like domain of RASSF1 tumour supproessor protein
    pfam16517
    Location:186 → 225
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121246255..121312220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243388.1 → XP_011241690.1  ras association domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    pfam16517
    Location:173 → 212
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl28922
    Location:37 → 166
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P51.1 GenPept UniProtKB/Swiss-Prot:Q99P51

Gene LinkOut

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