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Zfp184 zinc finger protein 184 (Kruppel-like) [ Mus musculus (house mouse) ]

Gene ID: 193452, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp184provided by MGI
Official Full Name
zinc finger protein 184 (Kruppel-like)provided by MGI
Primary source
MGI:MGI:1922244
See related
Ensembl:ENSMUSG00000006720 AllianceGenome:MGI:1922244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930500C15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; respiratory system; retina nuclear layer; submandibular gland primordium; and tooth. Orthologous to human ZNF184 (zinc finger protein 184). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 4.6), CNS E14 (RPKM 3.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp184 in Genome Data Viewer
Location:
13 A3.1; 13 8.08 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22129223..22144961)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21945053..21960791)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA aspartic acid 12 (anticodon GTC) Neighboring gene nuclear encoded tRNA serine 8 (anticodon AGA) Neighboring gene Tu translation elongation factor, mitochondrial pseudogene Neighboring gene nuclear encoded tRNA lysine 22 (anticodon TTT) Neighboring gene STARR-positive B cell enhancer ABC_E7210 Neighboring gene nuclear encoded tRNA methionine 8 (anticodon CAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. Foronda M, et al. Cell Rep, 2014 Jul 24. PMID 25043184, Free PMC Article
  2. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • MGC62472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 184

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360886.1 → NP_001347815.1  zinc finger protein 184 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589879
    Conserved Domains (3) summary
    COG5048
    Location:88 → 559
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:560 → 584
    zf-H2C2_2; Zinc-finger double domain

  2. NM_183014.1 → NP_898835.1  zinc finger protein 184 isoform 1

    See identical proteins and their annotated locations for NP_898835.1

    Status: VALIDATED

    Source sequence(s)
    BC053084
    Consensus CDS
    CCDS26302.1
    UniProtKB/Swiss-Prot
    Q7TSH9
    Related
    ENSMUSP00000135173.2, ENSMUST00000176511.8
    Conserved Domains (4) summary
    smart00349
    Location:28 → 88
    KRAB; krueppel associated box
    COG5048
    Location:163 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:635 → 659
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    22129223..22144961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157919.1 → XP_036013812.1  zinc finger protein 184 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:131 → 602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:27 → 68
    KRAB; KRAB box
    pfam13465
    Location:603 → 627
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006516597.5 → XP_006516660.1  zinc finger protein 184 isoform X1

    See identical proteins and their annotated locations for XP_006516660.1

    UniProtKB/Swiss-Prot
    Q7TSH9
    Related
    ENSMUSP00000100043.2, ENSMUST00000102978.8
    Conserved Domains (4) summary
    smart00349
    Location:28 → 88
    KRAB; krueppel associated box
    COG5048
    Location:163 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:635 → 659
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030247204.2 → XP_030103064.1  zinc finger protein 184 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:88 → 559
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:560 → 584
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006516596.5 → XP_006516659.1  zinc finger protein 184 isoform X1

    See identical proteins and their annotated locations for XP_006516659.1

    UniProtKB/Swiss-Prot
    Q7TSH9
    Conserved Domains (4) summary
    smart00349
    Location:28 → 88
    KRAB; krueppel associated box
    COG5048
    Location:163 → 634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:635 → 659
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030247205.1 → XP_030103065.1  zinc finger protein 184 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:88 → 559
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:212 → 232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:560 → 584
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSH9.1 GenPept UniProtKB/Swiss-Prot:Q7TSH9

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