Rad51ap1 RAD51 associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rad51ap1provided by MGI
Official Full Name: RAD51 associated protein 1provided by MGI
Primary source: MGI:MGI:1098224
See related: Ensembl:ENSMUSG00000030346 AllianceGenome:MGI:1098224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAB22; 2510006L10Rik
Summary: Predicted to enable nucleic acid binding activity. Acts upstream of or within DNA recombination. Located in chromosome and nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; gut; reproductive system; and trachea. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in liver E14 (RPKM 17.5), liver E14.5 (RPKM 14.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126900378..126916664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126923415..126939621, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-kappaB signaling pathway.
Title: The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.
RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
Title: RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.
RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
Title: RAD51AP1 Deficiency Reduces Tumor Growth by Targeting Stem Cell Self-Renewal.
VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
Title: VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.
RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-loop DNA binding	ISO Inferred from Sequence Orthology more info
enables D-loop DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA secondary structure binding	ISO Inferred from Sequence Orthology more info
enables DNA secondary structure binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA recombination	IPI Inferred from Physical Interaction more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reciprocal meiotic recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAD51-associated protein 1

Names: RAD51-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347455.1 → NP_001334384.1 RAD51-associated protein 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1

Source sequence(s)

AK077829, AK079525, AW457762, BB620338

Consensus CDS

CCDS85161.1

UniProtKB/Swiss-Prot

O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0

UniProtKB/TrEMBL

A0A0R4J1H1

Related

ENSMUSP00000107839.2, ENSMUST00000112220.8
NM_009013.4 → NP_033039.2 RAD51-associated protein 1 isoform 1

See identical proteins and their annotated locations for NP_033039.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK077829, AK079525, AW457762, BB620338

Consensus CDS

CCDS39644.1

UniProtKB/Swiss-Prot

O55219, Q8BP36, Q8C551, Q99L94, Q9D0J0

UniProtKB/TrEMBL

A0A0R4J1G4

Related

ENSMUSP00000107841.2, ENSMUST00000112221.8

Conserved Domains (2) summary

pfam10486
Location:126 → 268

PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

pfam15696
Location:293 → 331

RAD51_interact; RAD51 interacting motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

126900378..126916664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255239.1 → XP_030111099.1 RAD51-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam10500
Location:46 → 148

SR-25; Nuclear RNA-splicing-associated protein

pfam15696
Location:193 → 231

RAD51_interact; RAD51 interacting motif
XM_030255240.1 → XP_030111100.1 RAD51-associated protein 1 isoform X1

Conserved Domains (2) summary

pfam10500
Location:46 → 148

SR-25; Nuclear RNA-splicing-associated protein

pfam15696
Location:193 → 231

RAD51_interact; RAD51 interacting motif