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Raet1a retinoic acid early transcript 1, alpha [ Mus musculus (house mouse) ]

Gene ID: 19368, updated on 2-Nov-2024

Summary

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Official Symbol
Raet1aprovided by MGI
Official Full Name
retinoic acid early transcript 1, alphaprovided by MGI
Primary source
MGI:MGI:109477
See related
AllianceGenome:MGI:109477
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rae1a; Raet1; Rae1alpha; RAE-1alpha
Summary
Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within cellular response to exogenous dsRNA; cellular response to lipopolysaccharide; and defense response to bacterium. Located in plasma membrane. Is expressed in several structures, including branchial arch; heart; liver; placenta; and spleen. Orthologous to human RAET1G (retinoic acid early transcript 1G) and RAET1L (retinoic acid early transcript 1L). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
not in current annotation release
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Genomic context

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Location:
10; 10 A3

Bibliography

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Related articles in PubMed

  1. RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres. Popa N, et al. Glia, 2011 Jan. PMID 21046555
  2. Structural organization of the rae28 gene, a putative murine homologue of the Drosophila polyhomeotic gene. Abdul Motaleb M, et al. J Biochem, 1996 Oct. PMID 8947844
  3. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules. Zou Z, et al. J Biochem, 1996 Feb. PMID 8882725
  4. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. Nomura M, et al. J Biochem, 1996 Nov. PMID 8982867
  5. Murine NKG2D ligands: "double, double toil and trouble". Samarakoon A, et al. Mol Immunol, 2009 Mar. PMID 19081632, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal an unexpected role of RAE-1 in regulating adult SVZ neurogenesis by supporting stem/progenitor cells proliferation.
    Title: RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres.
Submit: New GeneRIF Correction

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinoic acid early-inducible protein 1-alpha
Names
RAE-1-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009016.1 → NP_033042.1  retinoic acid early-inducible protein 1-alpha precursor

    See identical proteins and their annotated locations for NP_033042.1

    Status: PROVISIONAL

    Source sequence(s)
    D64160
    UniProtKB/Swiss-Prot
    B9EI05, O08602
    Conserved Domains (1) summary
    cl08246
    Location:31 → 204
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08602.1 GenPept UniProtKB/Swiss-Prot:O08602

Gene LinkOut

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