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Rasal1 RAS protein activator like 1 (GAP1 like) [ Mus musculus (house mouse) ]

Gene ID: 19415, updated on 2-Nov-2024

Summary

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Official Symbol
Rasal1provided by MGI
Official Full Name
RAS protein activator like 1 (GAP1 like)provided by MGI
Primary source
MGI:MGI:1330842
See related
Ensembl:ENSMUSG00000029602 AllianceGenome:MGI:1330842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRASAL
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in positive regulation of dendrite extension. Predicted to be located in cytosol. Predicted to colocalize with plasma membrane. Is expressed in telencephalon mantle layer. Orthologous to human RASAL1 (RAS protein activator like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 12.7), frontal lobe adult (RPKM 9.6) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Rasal1 in Genome Data Viewer
Location:
5 F; 5 60.63 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120786105..120817662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120648040..120679597)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancers ABC_E2760 and ABC_E2174 Neighboring gene STARR-positive B cell enhancer ABC_E3610 Neighboring gene RBPJ interacting and tubulin associated 1 Neighboring gene DEAD box helicase 54 Neighboring gene cilia and flagella associated protein 73 Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene deltex 1, E3 ubiquitin ligase Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis. Xu X, et al. Nat Commun, 2018 Aug 29. PMID 30158531, Free PMC Article
  2. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. Allen M, et al. Gene, 1998 Sep 18. PMID 9751798
  3. Methylation determines fibroblast activation and fibrogenesis in the kidney. Bechtel W, et al. Nat Med, 2010 May. PMID 20418885, Free PMC Article
  4. Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis. Xu X, et al. Cardiovasc Res, 2015 Mar 1. PMID 25616414
  5. GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity. Thaker YR, et al. Nat Commun, 2019 Oct 22. PMID 31641113, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZAP-70-associated Rasal1 as a new negative regulator of T-cell activation and tumor immunity.Rasal1 binds to the kinase domain of ZAP-70.
    Title: GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
  2. Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis.
    Title: Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.
  3. Kidney fibrosis is associated with Rasal1 promoter hypermethylation, suppressed Rasal1 expression and suppressed Tet3 expression.
    Title: Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis.
  4. We demonstrate here that hypermethylation of RASAL1, encoding an inhibitor of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney
    Title: Methylation determines fibroblast activation and fibrogenesis in the kidney.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • AC125183.7

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rasGAP-activating-like protein 1
Names
ras GTPase-activating-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281999.2 → NP_001268928.1  rasGAP-activating-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and uses an alternate splice site in its 5' coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC125183
    Conserved Domains (6) summary
    cd05135
    Location:80 → 366
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    smart00323
    Location:60 → 422
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam00169
    Location:384 → 490
    PH; PH domain
    pfam00779
    Location:499 → 526
    BTK; BTK motif
    cl14603
    Location:33 → 72
    C2; C2 domain
    cl17171
    Location:370 → 507
    PH-like; Pleckstrin homology-like domain

  2. NM_001359144.1 → NP_001346073.1  rasGAP-activating-like protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC125183
    Consensus CDS
    CCDS19623.1
    UniProtKB/Swiss-Prot
    Q99K69, Q9Z268
    Conserved Domains (4) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:681 → 705
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

  3. NM_001359145.1 → NP_001346074.1  rasGAP-activating-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (3).
    Source sequence(s)
    AC125183
    Conserved Domains (4) summary
    cd05135
    Location:58 → 344
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:477 → 501
    BTK; BTK motif
    cl14603
    Location:1 → 50
    C2; C2 domain
    cl17171
    Location:348 → 485
    PH-like; Pleckstrin homology-like domain

  4. NM_001359146.1 → NP_001346075.1  rasGAP-activating-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (3).
    Source sequence(s)
    AC125183
    Conserved Domains (4) summary
    cd05135
    Location:58 → 344
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:477 → 501
    BTK; BTK motif
    cl14603
    Location:1 → 50
    C2; C2 domain
    cl17171
    Location:348 → 485
    PH-like; Pleckstrin homology-like domain

  5. NM_001359147.1 → NP_001346076.1  rasGAP-activating-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Variants 4, 5, and 6 all encode the same isoform (3).
    Source sequence(s)
    AC125183
    Conserved Domains (4) summary
    cd05135
    Location:58 → 344
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:477 → 501
    BTK; BTK motif
    cl14603
    Location:1 → 50
    C2; C2 domain
    cl17171
    Location:348 → 485
    PH-like; Pleckstrin homology-like domain

  6. NM_013832.5 → NP_038860.2  rasGAP-activating-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038860.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
    Source sequence(s)
    AC125183
    Consensus CDS
    CCDS19623.1
    UniProtKB/Swiss-Prot
    Q99K69, Q9Z268
    Related
    ENSMUSP00000031606.4, ENSMUST00000031606.10
    Conserved Domains (4) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:681 → 705
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120786105..120817662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254219.1 → XP_030110079.1  rasGAP-activating-like protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q99K69, Q9Z268
    Conserved Domains (4) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:681 → 705
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

  2. XM_006530210.2 → XP_006530273.1  rasGAP-activating-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006530273.1

    UniProtKB/Swiss-Prot
    Q99K69, Q9Z268
    Conserved Domains (4) summary
    cd05135
    Location:262 → 548
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:681 → 705
    BTK; BTK motif
    cl14603
    Location:6 → 126
    C2; C2 domain
    cl17171
    Location:552 → 689
    PH-like; Pleckstrin homology-like domain

  3. XM_030254221.2 → XP_030110081.1  rasGAP-activating-like protein 1 isoform X4

    Conserved Domains (3) summary
    pfam00779
    Location:323 → 347
    BTK; BTK motif
    cl02569
    Location:1 → 190
    RasGAP; Ras GTPase Activating Domain
    cl17171
    Location:194 → 331
    PH-like; Pleckstrin homology-like domain

  4. XM_030254220.2 → XP_030110080.1  rasGAP-activating-like protein 1 isoform X3

    Conserved Domains (4) summary
    cd05135
    Location:58 → 344
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:477 → 501
    BTK; BTK motif
    cl14603
    Location:1 → 50
    C2; C2 domain
    cl17171
    Location:348 → 485
    PH-like; Pleckstrin homology-like domain

  5. XM_006530208.3 → XP_006530271.2  rasGAP-activating-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd05135
    Location:237 → 523
    RasGAP_RASAL; Ras-GTPase Activating Domain of RASAL1 and similar proteins
    pfam00779
    Location:656 → 680
    BTK; BTK motif
    cl14603
    Location:109 → 229
    C2; C2 domain
    cl17171
    Location:527 → 664
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_003955601.1 RNA Sequence

  2. XR_004942463.1 RNA Sequence

  3. XR_003955600.2 RNA Sequence

  4. XR_003955599.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z268.2 GenPept UniProtKB/Swiss-Prot:Q9Z268

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