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Utp14b UTP14B small subunit processome component [ Mus musculus (house mouse) ]

Gene ID: 195434, updated on 28-Oct-2024

Summary

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Official Symbol
Utp14bprovided by MGI
Official Full Name
UTP14B small subunit processome componentprovided by MGI
Primary source
MGI:MGI:2445092
See related
Ensembl:ENSMUSG00000079470 AllianceGenome:MGI:2445092
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
jsd; 4932411L21Rik
Summary
Acts upstream of or within spermatogenesis. Predicted to be located in cytosol. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP14A (UTP14A small subunit processome component) and UTP14C (UTP14C small subunit processome component). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in colon adult (RPKM 6.7), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
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Genomic context

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See Utp14b in Genome Data Viewer
Location:
1 C4; 1 40.84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78635600..78645305)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78657825..78667601)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683 Neighboring gene STARR-seq mESC enhancer starr_01433 Neighboring gene STARR-positive B cell enhancer ABC_E5775 Neighboring gene acyl-CoA synthetase long-chain family member 3 Neighboring gene predicted gene, 51635 Neighboring gene predicted gene, 38631 Neighboring gene predicted gene, 33693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of sperm in juvenile spermatogonial depletion (jsd) mutant mice is ascribed to a defect of intratubular environment to support germ cell differentiation. Mizunuma M, et al. J Cell Physiol, 1992 Jan. PMID 1346141
  2. Restoration of spermatogenesis and fertility in azoospermic mutant mice by suppression and reelevation of testosterone followed by intracytoplasmic sperm injection. Tohda A, et al. Biol Reprod, 2002 Jan. PMID 11751268
  3. Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature. Shetty G, et al. Endocrinology, 2011 Sep. PMID 21733828, Free PMC Article
  4. Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice. Shetty G, et al. Endocrinology, 2004 Jan. PMID 14500567
  5. Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice. Tohda A, et al. Biol Reprod, 2001 Aug. PMID 11466222

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In adult male mice homozygous for the juvenile spermatogonial depletion (Utp14b jsd) mutation in the Utp14b gene, type A spermatogonia proliferate but undergo apoptosis before differentiation.
    Title: p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.
  2. inhibition of spermatogonial differentiation in jsd mice is a result of testosterone acting through the AR only at scrotal temperatures
    Title: Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations.
  3. The novel cell-type-specific promoter for Utp14b likely evolved later, as the protein may have acquired a germ cell-specific function in spermatid development.
    Title: Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 14 homolog B
Names
UTP14, U3 small nucleolar ribonucleoprotein, homolog B
juvenile spermatogonial depletion protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001981.4 → NP_001001981.2  U3 small nucleolar RNA-associated protein 14 homolog B

    See identical proteins and their annotated locations for NP_001001981.2

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15086.1
    UniProtKB/TrEMBL
    B2RUE3, E9Q9S3
    Related
    ENSMUSP00000052149.6, ENSMUST00000053760.12
    Conserved Domains (1) summary
    pfam04615
    Location:55 → 741
    Utp14; Utp14 protein

  2. NM_001136226.2 → NP_001129698.1  U3 small nucleolar RNA-associated protein 14 homolog B

    See identical proteins and their annotated locations for NP_001129698.1

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15086.1
    UniProtKB/TrEMBL
    B2RUE3, E9Q9S3
    Related
    ENSMUSP00000121391.2, ENSMUST00000151622.2
    Conserved Domains (1) summary
    pfam04615
    Location:55 → 741
    Utp14; Utp14 protein

  3. NM_001409066.1 → NP_001395995.1  U3 small nucleolar RNA-associated protein 14 homolog B

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/TrEMBL
    E9Q9S3

  4. NM_001409067.1 → NP_001395996.1  U3 small nucleolar RNA-associated protein 14 homolog B

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/TrEMBL
    E9Q9S3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78635600..78645305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6EJB6.2 GenPept UniProtKB/Swiss-Prot:Q6EJB6

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