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Zfp691 zinc finger protein 691 [ Mus musculus (house mouse) ]

Gene ID: 195522, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp691provided by MGI
Official Full Name
zinc finger protein 691provided by MGI
Primary source
MGI:MGI:3041163
See related
Ensembl:ENSMUSG00000045268 AllianceGenome:MGI:3041163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf691; 6430544H17Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF691 (zinc finger protein 691). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 8.1), ovary adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp691 in Genome Data Viewer
Location:
4 D2.1; 4 55.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119026710..119031429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119169516..119174195, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6204 Neighboring gene predicted gene, 52706 Neighboring gene STARR-positive B cell enhancer ABC_E3506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118781841-118782024 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_11226 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:118800270-118800453 Neighboring gene predicted gene 12867 Neighboring gene STARR-positive B cell enhancer ABC_E422 Neighboring gene erythroblast membrane-associated protein Neighboring gene small vasohibin binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC118413

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 691

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145935.1 → NP_001139407.1  zinc finger protein 691

    See identical proteins and their annotated locations for NP_001139407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK032431, AL606975, BC108395
    Consensus CDS
    CCDS18570.1
    UniProtKB/TrEMBL
    A2A7P4
    Related
    ENSMUSP00000136119.2, ENSMUST00000179290.8
    Conserved Domains (3) summary
    COG5048
    Location:70 → 234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197 → 217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001145936.1 → NP_001139408.1  zinc finger protein 691

    See identical proteins and their annotated locations for NP_001139408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK032431, AL606975, BY233872
    Consensus CDS
    CCDS18570.1
    UniProtKB/TrEMBL
    A2A7P4
    Related
    ENSMUSP00000101962.4, ENSMUST00000106355.5
    Conserved Domains (3) summary
    COG5048
    Location:70 → 234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197 → 217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_183140.3 → NP_898963.2  zinc finger protein 691

    See identical proteins and their annotated locations for NP_898963.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK032431, AL606975, BC108395
    Consensus CDS
    CCDS18570.1
    UniProtKB/TrEMBL
    A2A7P4
    Related
    ENSMUSP00000053013.5, ENSMUST00000052715.10
    Conserved Domains (3) summary
    COG5048
    Location:70 → 234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197 → 217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119026710..119031429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163923.1 → XP_036019816.1  zinc finger protein 691 isoform X1

    UniProtKB/TrEMBL
    A2A7P4
    Conserved Domains (3) summary
    COG5048
    Location:70 → 234
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:197 → 217
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:251 → 273
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TDE8.1 GenPept UniProtKB/Swiss-Prot:Q3TDE8

Gene LinkOut

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