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Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 195646, updated on 2-Nov-2024

Summary

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Official Symbol
Hs3st2provided by MGI
Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 2provided by MGI
Primary source
MGI:MGI:1333802
See related
Ensembl:ENSMUSG00000046321 AllianceGenome:MGI:1333802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430516N12Rik; A830061E14Rik
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and skeleton. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Hs3st2 in Genome Data Viewer
Location:
7 F2; 7 65.07 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120990785..121196555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121391585..121501768)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20061 Neighboring gene predicted gene, 36736 Neighboring gene STARR-seq mESC enhancer starr_20062 Neighboring gene STARR-seq mESC enhancer starr_20063 Neighboring gene STARR-positive B cell enhancer mm9_chr7:128623661-128623961 Neighboring gene predicted gene, 39081 Neighboring gene RIKEN cDNA 4933432K03 gene Neighboring gene RIKEN cDNA 1700025J12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10470 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene STARR-positive B cell enhancer ABC_E6594 Neighboring gene STARR-positive B cell enhancer ABC_E8205 Neighboring gene STARR-seq mESC enhancer starr_20066 Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene predicted gene, 36848

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity. Thacker BE, et al. ACS Chem Biol, 2016 Apr 15. PMID 26731579, Free PMC Article
  2. microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2. Zhang F, et al. Cell Signal, 2023 Feb. PMID 36423858
  3. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. Liu J, et al. J Biol Chem, 1999 Feb 19. PMID 9988768
  4. Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. Hasegawa H, et al. J Comp Neurol, 2008 Dec 1. PMID 18839409, Free PMC Article
  5. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2.
    Title: microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 2
Names
heparan sulfate 3-O-sulfotransferase 2
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
NP_001074796.1
NP_001406126.1
XP_006507527.1
XP_006507529.1
XP_030098100.1
XP_030098101.1
XP_036008693.1
XP_036008694.1
XP_036008695.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081327.2 → NP_001074796.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001074796.1

    Status: VALIDATED

    Source sequence(s)
    AC098715, AC125331
    Consensus CDS
    CCDS40115.1
    UniProtKB/Swiss-Prot
    Q673U1, Q8BLP1, Q8C055
    Related
    ENSMUSP00000081678.4, ENSMUST00000084628.5
    Conserved Domains (1) summary
    pfam00685
    Location:114 → 351
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001419197.1 → NP_001406126.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC098715, AC125331

RNA

  1. NR_185034.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC098715, AC125331

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120990785..121196555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152801.1 → XP_036008694.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

    Conserved Domains (1) summary
    pfam00685
    Location:2 → 187
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_030242240.2 → XP_030098100.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

    Conserved Domains (1) summary
    pfam00685
    Location:2 → 187
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_036152802.1 → XP_036008695.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X7

    Conserved Domains (1) summary
    cl21551
    Location:131 → 181
    Sulfotransfer_3; Sulfotransferase family

  4. XM_006507464.1 → XP_006507527.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:131 → 368
    Sulfotransfer_1; Sulfotransferase domain

  5. XM_030242241.1 → XP_030098101.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X8

    Conserved Domains (1) summary
    cl21551
    Location:131 → 184
    Sulfotransfer_3; Sulfotransferase family

  6. XM_006507466.4 → XP_006507529.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4

    Conserved Domains (1) summary
    cl21551
    Location:131 → 178
    Sulfotransfer_3; Sulfotransferase family

  7. XM_036152800.1 → XP_036008693.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

    Conserved Domains (1) summary
    cl21551
    Location:131 → 182
    Sulfotransfer_3; Sulfotransferase family

RNA

  1. XR_004934044.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177575.2: Suppressed sequence

    Description
    NM_177575.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q673U1.2 GenPept UniProtKB/Swiss-Prot:Q673U1

Gene LinkOut

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