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Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 19714, updated on 2-Nov-2024

Summary

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Official Symbol
Rev3lprovided by MGI
Official Full Name
REV3 like, DNA directed polymerase zeta catalytic subunitprovided by MGI
Primary source
MGI:MGI:1337131
See related
Ensembl:ENSMUSG00000019841 AllianceGenome:MGI:1337131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rev; Rev3; Sez4
Summary
Predicted to enable DNA-directed DNA polymerase activity. Acts upstream of or within DNA repair. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and nose. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 11.7), whole brain E14.5 (RPKM 9.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Rev3l in Genome Data Viewer
Location:
10 B1; 10 21.04 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39607557..39751207)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39731561..39875211)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130307A14 gene Neighboring gene predicted gene 8899 Neighboring gene predicted gene, 53621 Neighboring gene STARR-seq mESC enhancer starr_26404 Neighboring gene STARR-seq mESC enhancer starr_26405 Neighboring gene STARR-seq mESC enhancer starr_26406 Neighboring gene predicted gene, 22105 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene major facilitator superfamily domain containing 4B4 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sez4 gene encoding an elongation subunit of DNA polymerase zeta is required for normal embryogenesis. Kajiwara K, et al. Genes Cells, 2001 Feb. PMID 11260255
  2. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. Schenten D, et al. J Exp Med, 2009 Feb 16. PMID 19204108, Free PMC Article
  3. An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic death. O-Wang J, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051777
  4. Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions. Jansen JG, et al. DNA Repair (Amst), 2009 Dec 3. PMID 19783229
  5. Error-free replicative bypass of (6-4) photoproducts by DNA polymerase zeta in mouse and human cells. Yoon JH, et al. Genes Dev, 2010 Jan 15. PMID 20080950, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of DNA polymerase zeta engages an innate immune response.
    Title: Disruption of DNA polymerase ζ engages an innate immune response.
  2. The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
    Title: The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
  3. The role of DNA polymerase zeta in benzo[a]pyrene-induced mutagenesis in the mouse lung.
    Title: The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.
  4. DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
    Title: DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
  5. A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
    Title: A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
  6. The roles of POLZ in DNA replication and repair have been summarized. (Review)
    Title: DNA polymerase ζ in DNA replication and repair.
  7. Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L
    Title: DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
  8. A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
    Title: A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
  9. the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta
    Title: The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.
  10. results can be unified by a model in which slowly dividing cells accumulate replication-associated DNA breaks but otherwise survive Rev3L deletion, but functional polzeta is essential for responses requiring rapid proliferation
    Title: Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (14)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in error-prone translesion synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zeta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of zeta DNA polymerase complex ISO
Inferred from Sequence Orthology
more info
  
part_of zeta DNA polymerase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA polymerase zeta catalytic subunit
Names
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like
seizure-related protein 4
NP_035394.2
XP_006512685.1
XP_006512686.1
XP_006512687.1
XP_036011601.1
XP_036011602.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011264.3 → NP_035394.2  DNA polymerase zeta catalytic subunit

    See identical proteins and their annotated locations for NP_035394.2

    Status: VALIDATED

    Source sequence(s)
    AB031049, AC118733, AC119943
    Consensus CDS
    CCDS23790.1
    UniProtKB/Swiss-Prot
    E9Q1X0, Q61493, Q9JMD6, Q9QWX6
    Related
    ENSMUSP00000019986.7, ENSMUST00000019986.13
    Conserved Domains (5) summary
    cd05778
    Location:2286 → 2524
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2550 → 2998
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam00136
    Location:2550 → 2997
    DNA_pol_B; DNA polymerase family B
    pfam14260
    Location:3034 → 3101
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:746 → 1132
    DUF4683; Domain of unknown function (DUF4683)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    39607557..39751207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512622.3 → XP_006512685.1  DNA polymerase zeta catalytic subunit isoform X1

    Conserved Domains (5) summary
    cd05778
    Location:2287 → 2525
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2551 → 2999
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:6 → 195
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:3035 → 3102
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:747 → 1133
    DUF4683; Domain of unknown function (DUF4683)

  2. XM_006512623.5 → XP_006512686.1  DNA polymerase zeta catalytic subunit isoform X2

    Conserved Domains (5) summary
    cd05778
    Location:2209 → 2447
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2473 → 2921
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:4 → 117
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:2957 → 3024
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:669 → 1055
    DUF4683; Domain of unknown function (DUF4683)

  3. XM_036155709.1 → XP_036011602.1  DNA polymerase zeta catalytic subunit isoform X4

    Conserved Domains (5) summary
    cd05778
    Location:1941 → 2179
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2205 → 2653
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam14260
    Location:2689 → 2756
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:407 → 787
    DUF4683; Domain of unknown function (DUF4683)
    cd22287
    Location:1525 → 1547
    REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins

  4. XM_036155708.1 → XP_036011601.1  DNA polymerase zeta catalytic subunit isoform X4

    Conserved Domains (5) summary
    cd05778
    Location:1941 → 2179
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2205 → 2653
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    pfam14260
    Location:2689 → 2756
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:407 → 787
    DUF4683; Domain of unknown function (DUF4683)
    cd22287
    Location:1525 → 1547
    REV3L_RBD; REV7 binding domain found in protein reversionless 3-like (REV3L) and similar proteins

  5. XM_006512624.5 → XP_006512687.1  DNA polymerase zeta catalytic subunit isoform X3

    Conserved Domains (5) summary
    cd05778
    Location:2208 → 2446
    DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
    cd05534
    Location:2472 → 2920
    POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
    PTZ00166
    Location:4 → 117
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:2956 → 3023
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    pfam15735
    Location:668 → 1054
    DUF4683; Domain of unknown function (DUF4683)

RNA

  1. XR_004936129.1 RNA Sequence

    Related
    ENSMUST00000131186.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61493.3 GenPept UniProtKB/Swiss-Prot:Q61493

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