U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FCSK fucose kinase [ Homo sapiens (human) ]

Gene ID: 197258, updated on 27-Nov-2024

Summary

Official Symbol
FCSKprovided by HGNC
Official Full Name
fucose kinaseprovided by HGNC
Primary source
HGNC:HGNC:29500
See related
Ensembl:ENSG00000157353 MIM:608675; AllianceGenome:HGNC:29500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FUK; CDGF2; 1110046B12Rik
Summary
The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 3.1), kidney (RPKM 2.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FCSK in Genome Data Viewer
Location:
16q22.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70454595..70480274)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76265623..76291305)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70488498..70514177)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 23, pseudogene Neighboring gene uncharacterized LOC124903708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70500319-70500820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70500821-70501320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:70504733-70505668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11065 Neighboring gene Sharpr-MPRA regulatory region 8991 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70558263-70559000 Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene splicing factor 3b subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Congenital disorder of glycosylation with defective fucosylation 2
MedGen: C5193028 OMIM: 618324 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fucokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fucokinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables fucokinase activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in GDP-L-fucose biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in GDP-L-fucose salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in GDP-L-fucose salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to dopamine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
L-fucose kinase
Names
fucokinase
NP_659496.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145059.3NP_659496.2  L-fucose kinase

    See identical proteins and their annotated locations for NP_659496.2

    Status: REVIEWED

    Source sequence(s)
    AJ441184, BC013735, BC032542
    Consensus CDS
    CCDS10891.2
    UniProtKB/Swiss-Prot
    Q5PSM3, Q5XKL6, Q6ZRA0, Q8N0W3, Q96MT9
    UniProtKB/TrEMBL
    B2RDL5
    Related
    ENSP00000288078.6, ENST00000288078.11
    Conserved Domains (3) summary
    COG2605
    Location:712996
    COG2605; Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]
    pfam00288
    Location:827894
    GHMP_kinases_N; GHMP kinases N terminal domain
    pfam07959
    Location:97495
    Fucokinase; L-fucokinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70454595..70480274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    76265623..76291305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)