EIF5A eukaryotic translation initiation factor 5A [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF5Aprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 5Aprovided by HGNC
Primary source: HGNC:HGNC:3300
See related: Ensembl:ENSG00000132507 MIM:600187; AllianceGenome:HGNC:3300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI
Summary: Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7306999..7312463)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7210983..7216447)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7210318..7215782)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
Title: High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Title: Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
Title: Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Title: Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.
Title: Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.
LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis.
Title: LncRNA FOXP4-AS promotes the progression of non-small cell lung cancer by regulating the miR-3184-5p/EIF5A axis.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Faundes-Banka syndrome MedGen: C5543554 OMIM: 619376 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef downregulates the expression of eukaryotic translation initiation factor 5A (EIF5A) protein in Nef-transfected SupT1 cells	PubMed
Rev	rev	eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export	PubMed
	rev	eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev	PubMed
	rev	eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA	PubMed
	rev	eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity	PubMed
	rev	eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev	PubMed
	rev	eIF-5A interacts with the activation domain of Rev (amino acids 75-83)	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH67341 (e-PCR)
- UniSTS:88764

RH39404 (e-PCR)
- UniSTS:86005

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U6 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translational elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in annulate lamellae	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 5A-1

Names: eukaryotic initiation factor 5A; rev-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143760.1 → NP_001137232.1 eukaryotic translation initiation factor 5A-1 isoform A

See identical proteins and their annotated locations for NP_001137232.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes the longer isoform (A).

Source sequence(s)

AC026954, AY129319

Consensus CDS

CCDS45601.1

UniProtKB/TrEMBL

I3L504

Related

ENSP00000336702.7, ENST00000336452.11

Conserved Domains (1) summary

cl28432
Location:31 → 180

PRK03999; translation initiation factor IF-5A; Provisional
NM_001143761.1 → NP_001137233.1 eukaryotic translation initiation factor 5A-1 isoform B

See identical proteins and their annotated locations for NP_001137233.1

Status: VALIDATED

Description

Transcript Variant: This variant (C) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.

Source sequence(s)

AC026954, AY129321

Consensus CDS

CCDS11099.1

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

UniProtKB/TrEMBL

I3L397

Related

ENSP00000390677.2, ENST00000419711.6

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001143762.2 → NP_001137234.1 eukaryotic translation initiation factor 5A-1 isoform B

See identical proteins and their annotated locations for NP_001137234.1

Status: VALIDATED

Description

Transcript Variant: This variant (D) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.

Source sequence(s)

AC026954, AY129322, BG479628

Consensus CDS

CCDS11099.1

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

UniProtKB/TrEMBL

I3L397

Related

ENSP00000396073.2, ENST00000416016.2

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001370420.1 → NP_001357349.1 eukaryotic translation initiation factor 5A-1 isoform B

Status: VALIDATED

Source sequence(s)

AC026954

Consensus CDS

CCDS11099.1

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

UniProtKB/TrEMBL

I3L397

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001370421.1 → NP_001357350.1 eukaryotic translation initiation factor 5A-1 isoform B

Status: VALIDATED

Source sequence(s)

AC026954

Consensus CDS

CCDS11099.1

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

UniProtKB/TrEMBL

I3L397

Related

ENSP00000460284.1, ENST00000573714.5

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional
NM_001970.5 → NP_001961.1 eukaryotic translation initiation factor 5A-1 isoform B

See identical proteins and their annotated locations for NP_001961.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.

Source sequence(s)

AC026954, AY129320, CB111036

Consensus CDS

CCDS11099.1

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

UniProtKB/TrEMBL

I3L397

Related

ENSP00000336776.8, ENST00000336458.13

Conserved Domains (1) summary

cl30809
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

7306999..7312463

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024301.3 → XP_016879790.1 eukaryotic translation initiation factor 5A-1 isoform X1

UniProtKB/TrEMBL

B7Z8F1
XM_047435523.1 → XP_047291479.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_011523710.3 → XP_011522012.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_011522012.1

UniProtKB/TrEMBL

B7Z8F1
XM_011523712.4 → XP_011522014.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_011522014.1

UniProtKB/TrEMBL

B7Z8F1
XM_011523711.3 → XP_011522013.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_011522013.1

UniProtKB/TrEMBL

B7Z8F1
XM_047435524.1 → XP_047291480.1 eukaryotic translation initiation factor 5A-1 isoform X2

UniProtKB/Swiss-Prot

A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
XM_011523713.3 → XP_011522015.1 eukaryotic translation initiation factor 5A-1 isoform X1

See identical proteins and their annotated locations for XP_011522015.1

UniProtKB/TrEMBL

B7Z8F1

Reference GRCh38.p14 PATCHES

Genomic

NW_021160020.1 Reference GRCh38.p14 PATCHES

Range

65364..70828

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332651.1 → XP_054188626.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054332647.1 → XP_054188622.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054332648.1 → XP_054188623.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054332649.1 → XP_054188624.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054332652.1 → XP_054188627.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054332650.1 → XP_054188625.1 eukaryotic translation initiation factor 5A-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

7210983..7216447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054315317.1 → XP_054171292.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054315313.1 → XP_054171288.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054315314.1 → XP_054171289.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054315315.1 → XP_054171290.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054315318.1 → XP_054171293.1 eukaryotic translation initiation factor 5A-1 isoform X1
XM_054315316.1 → XP_054171291.1 eukaryotic translation initiation factor 5A-1 isoform X1