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SLC5A9 solute carrier family 5 member 9 [ Homo sapiens (human) ]

Gene ID: 200010, updated on 2-Nov-2024

Summary

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Official Symbol
SLC5A9provided by HGNC
Official Full Name
solute carrier family 5 member 9provided by HGNC
Primary source
HGNC:HGNC:22146
See related
Ensembl:ENSG00000117834 MIM:620216; AllianceGenome:HGNC:22146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT4
Summary
Predicted to enable D-glucose:sodium symporter activity. Predicted to be involved in hexose transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in duodenum (RPKM 15.3), small intestine (RPKM 14.5) and 4 other tissues See more
Orthologs
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Genomic context

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See SLC5A9 in Genome Data Viewer
Location:
1p33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (48222716..48248638)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (48090656..48127385)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (48688388..48714310)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2794 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:48558178-48559377 Neighboring gene cytochrome P450 family 46 subfamily A member 4, pseudogene Neighboring gene Skint1 like (pseudogene) Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:48674527-48675206 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:48679855-48680592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:48697245-48697746 Neighboring gene spermatogenesis associated 6 Neighboring gene protein phosphatase 1 regulatory subunit 8 pseudogene 1 Neighboring gene RNA, U6 small nuclear 723, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Tazawa S, et al. Life Sci, 2005 Jan 14. PMID 15607332
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Flachsbart F, et al. Mutat Res, 2010 Dec 10. PMID 20800603
  3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
  4. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
  2. SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc).
    Title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC132517, MGC132523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-affinity D-glucose:sodium symporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sodium/glucose cotransporter 4
Names
Na(+)/glucose cotransporter 4
hSGLT4
solute carrier family 5 (sodium/glucose cotransporter), member 9
solute carrier family 5 (sodium/sugar cotransporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011547.3 → NP_001011547.2  sodium/glucose cotransporter 4 isoform 2

    See identical proteins and their annotated locations for NP_001011547.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AI767388, AL109659, BC104857
    Consensus CDS
    CCDS30709.2
    UniProtKB/Swiss-Prot
    B3KY87, B7ZL45, B7ZL47, E9PAK4, E9PJ08, Q2M3M2, Q5TET3
    Related
    ENSP00000401730.2, ENST00000438567.7
    Conserved Domains (1) summary
    cd11488
    Location:37 → 681
    SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain

  2. NM_001135181.2 → NP_001128653.1  sodium/glucose cotransporter 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI767388, AL109659, BC104857, BX648549
    Consensus CDS
    CCDS44136.1
    UniProtKB/Swiss-Prot
    Q2M3M2
    Related
    ENSP00000236495.5, ENST00000236495.9
    Conserved Domains (1) summary
    cd11488
    Location:37 → 706
    SLC5sbd_SGLT4; Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    48222716..48248638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448583.1 → XP_047304539.1  sodium/glucose cotransporter 4 isoform X1

    Related
    ENST00000493837.6

  2. XM_011540924.3 → XP_011539226.1  sodium/glucose cotransporter 4 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:37 → 719
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_047448585.1 → XP_047304541.1  sodium/glucose cotransporter 4 isoform X3

  4. XM_047448592.1 → XP_047304548.1  sodium/glucose cotransporter 4 isoform X5

  5. XM_011540925.3 → XP_011539227.1  sodium/glucose cotransporter 4 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:37 → 641
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_047448596.1 → XP_047304552.1  sodium/glucose cotransporter 4 isoform X7

  7. XM_011540929.3 → XP_011539231.1  sodium/glucose cotransporter 4 isoform X9

    Conserved Domains (1) summary
    cl00456
    Location:37 → 444
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_047448593.1 → XP_047304549.1  sodium/glucose cotransporter 4 isoform X6

  9. XM_011540927.2 → XP_011539229.1  sodium/glucose cotransporter 4 isoform X8

    Conserved Domains (1) summary
    cl00456
    Location:91 → 586
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    48090656..48127385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334923.1 → XP_054190898.1  sodium/glucose cotransporter 4 isoform X11

  2. XM_054334924.1 → XP_054190899.1  sodium/glucose cotransporter 4 isoform X5

  3. XM_054334918.1 → XP_054190893.1  sodium/glucose cotransporter 4 isoform X1

  4. XM_054334919.1 → XP_054190894.1  sodium/glucose cotransporter 4 isoform X2

  5. XM_054334920.1 → XP_054190895.1  sodium/glucose cotransporter 4 isoform X10

  6. XM_054334921.1 → XP_054190896.1  sodium/glucose cotransporter 4 isoform X3

  7. XM_054334922.1 → XP_054190897.1  sodium/glucose cotransporter 4 isoform X4

  8. XM_054334926.1 → XP_054190901.1  sodium/glucose cotransporter 4 isoform X7

  9. XM_054334928.1 → XP_054190903.1  sodium/glucose cotransporter 4 isoform X9

  10. XM_054334925.1 → XP_054190900.1  sodium/glucose cotransporter 4 isoform X6

  11. XM_054334927.1 → XP_054190902.1  sodium/glucose cotransporter 4 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2M3M2.2 GenPept UniProtKB/Swiss-Prot:Q2M3M2

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