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NUDT17 nudix hydrolase 17 [ Homo sapiens (human) ]

Gene ID: 200035, updated on 2-Nov-2024

Summary

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Official Symbol
NUDT17provided by HGNC
Official Full Name
nudix hydrolase 17provided by HGNC
Primary source
HGNC:HGNC:26618
See related
Ensembl:ENSG00000186364 AllianceGenome:HGNC:26618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable NADH pyrophosphatase activity. Predicted to be involved in NAD catabolic process; NADH metabolic process; and NADP catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in skin (RPKM 3.7), endometrium (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See NUDT17 in Genome Data Viewer
Location:
1q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (145845630..145848954)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (144962433..144965757)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (145586114..145589438, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD160 molecule Neighboring gene ring finger protein 115 Neighboring gene MPRA-validated peak399 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr1:145629590-145630098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1611 Neighboring gene RNA polymerase III subunit C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1613 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1614 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:145584188-145585387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1265 Neighboring gene microRNA 6736 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145562391-145562908 Neighboring gene ankyrin repeat domain 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145556249-145557232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1267

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association between NUDT17 polymorphisms and breast cancer risk. Han J, et al. Expert Rev Mol Diagn, 2024 May. PMID 38756100
  2. Multiple Nudix family proteins possess mRNA decapping activity. Song MG, et al. RNA, 2013 Mar. PMID 23353937, Free PMC Article
  3. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association between NUDT17 polymorphisms and breast cancer risk.
    Title: Association between NUDT17 polymorphisms and breast cancer risk.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • FLJ34433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH pyrophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADH metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleoside diphosphate-linked moiety X motif 17
Names
nudix (nucleoside diphosphate linked moiety X)-type motif 17
nudix motif 17
NP_001012776.1
XP_011507562.1
XP_016856049.1
XP_047304603.1
XP_054190904.1
XP_054190905.1
XP_054190906.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012758.3 → NP_001012776.1  nucleoside diphosphate-linked moiety X motif 17

    See identical proteins and their annotated locations for NP_001012776.1

    Status: VALIDATED

    Source sequence(s)
    AC239808
    Consensus CDS
    CCDS72865.1
    UniProtKB/Swiss-Prot
    P0C025
    Related
    ENSP00000334437.5, ENST00000334513.6
    Conserved Domains (1) summary
    cd04694
    Location:92 → 234
    Nudix_Hydrolase_35; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    145845630..145848954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509260.3 → XP_011507562.1  nucleoside diphosphate-linked moiety X motif 17 isoform X1

    Conserved Domains (1) summary
    cl00447
    Location:55 → 164
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

  2. XM_047448647.1 → XP_047304603.1  nucleoside diphosphate-linked moiety X motif 17 isoform X2

    Related
    ENST00000477878.5

  3. XM_017000560.2 → XP_016856049.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

RNA

  1. XR_007095715.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    144962433..144965757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334929.1 → XP_054190904.1  nucleoside diphosphate-linked moiety X motif 17 isoform X1

  2. XM_054334930.1 → XP_054190905.1  nucleoside diphosphate-linked moiety X motif 17 isoform X2

  3. XM_054334931.1 → XP_054190906.1  nucleoside diphosphate-linked moiety X motif 17 isoform X3

RNA

  1. XR_008485958.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C025.2 GenPept UniProtKB/Swiss-Prot:P0C025

Gene LinkOut

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