Sub1 SUB1 homolog, transcriptional regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sub1provided by MGI
Official Full Name: SUB1 homolog, transcriptional regulatorprovided by MGI
Primary source: MGI:MGI:104811
See related: Ensembl:ENSMUSG00000022205 AllianceGenome:MGI:104811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P9; P15; Pc4; Rpo2tc1
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase II promoter clearance; negative regulation of DNA duplex unwinding; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.9 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (11981422..11996091, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (11981336..11996038, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/beta-catenin pathway.
Title: PC4 promotes bladder cancer progression and stemness by directly interacting with Sp1 to transcriptionally activate the Wnt5a/β-catenin pathway.
These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity.
Title: Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction.
Results suggest that positive cofactor 4 (Pc4) has an important role in inducing spontaneous somatic cell reprogramming via up-regulation of key pluripotency genes.
Title: An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency.
Report recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.
Title: Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.
Redox-mediated upregulation of hepatocyte iNOS transcription requires an HNF-4alpha-PC4 transcriptional complex
Title: Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sub1 (e-PCR), detects polymorphism
- UniSTS:479285

RH128729 (e-PCR)
- UniSTS:212037

RH143136 (e-PCR)
- UniSTS:232383

AI842364 (e-PCR)
- UniSTS:164573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II promoter clearance	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II promoter clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription initiation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activated RNA polymerase II transcriptional coactivator p15

Names: RNA polymerase II transcriptional coactivator; p14; positive cofactor 4; single-stranded DNA-binding protein p9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411715.1 → NP_001398644.1 activated RNA polymerase II transcriptional coactivator p15

Status: VALIDATED

Source sequence(s)

AC121860

UniProtKB/Swiss-Prot

P11031, Q3UJR5, Q543N2
NM_011294.4 → NP_035424.1 activated RNA polymerase II transcriptional coactivator p15

See identical proteins and their annotated locations for NP_035424.1

Status: VALIDATED

Source sequence(s)

AC121860

Consensus CDS

CCDS27387.1

UniProtKB/Swiss-Prot

P11031, Q3UJR5, Q543N2

Related

ENSMUSP00000022816.9, ENSMUST00000022816.15

Conserved Domains (1) summary

pfam02229
Location:68 → 115

PC4; Transcriptional Coactivator p15 (PC4)