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LYRM9 LYR motif containing 9 [ Homo sapiens (human) ]

Gene ID: 201229, updated on 2-Nov-2024

Summary

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Official Symbol
LYRM9provided by HGNC
Official Full Name
LYR motif containing 9provided by HGNC
Primary source
HGNC:HGNC:27314
See related
Ensembl:ENSG00000232859 AllianceGenome:HGNC:27314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD24; C17orf108
Summary
Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 12.9), brain (RPKM 12.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See LYRM9 in Genome Data Viewer
Location:
17q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (27878358..27893365, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (28819756..28834759, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26205384..26220391, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26110033-26110532 Neighboring gene nitric oxide synthase 2 Neighboring gene NOS2 5' regulatory region Neighboring gene uncharacterized LOC124903961 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:26208991-26209681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26215109-26216060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26216061-26217012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8331 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26241118-26241431 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:26242505-26243362 Neighboring gene long intergenic non-protein coding RNA 1992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11915 Neighboring gene uncharacterized LOC124903962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26284095-26284956 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:26286038-26286747 Neighboring gene Sharpr-MPRA regulatory region 4282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11916 Neighboring gene CRISPRi-validated cis-regulatory element chr17.1404 Neighboring gene MPRA-validated peak2774 silencer Neighboring gene uncharacterized LOC124900402

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. Dibley MG, et al. Mol Cell Proteomics, 2020 Jan. PMID 31666358, Free PMC Article
  2. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. van der Valk RJ, et al. J Allergy Clin Immunol, 2014 Jul. PMID 24315451, Free PMC Article
  3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
LYR motif-containing protein 9
Names
UPF0631 protein C17orf108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076680.3 → NP_001070148.1  LYR motif-containing protein 9

    See identical proteins and their annotated locations for NP_001070148.1

    Status: VALIDATED

    Source sequence(s)
    AC005697, AI804732, DB474433, DR155808
    Consensus CDS
    CCDS45631.1
    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8
    UniProtKB/TrEMBL
    D6RAR2
    Related
    ENSP00000368396.3, ENST00000379102.8
    Conserved Domains (1) summary
    pfam13232
    Location:11 → 70
    Complex1_LYR_1; Complex1_LYR-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    27878358..27893365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435563.1 → XP_047291519.1  LYR motif-containing protein 9 isoform X3

    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8

  2. XM_047435562.1 → XP_047291518.1  LYR motif-containing protein 9 isoform X3

    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8
    Related
    ENSP00000368397.2, ENST00000379103.7

  3. XM_024450636.2 → XP_024306404.1  LYR motif-containing protein 9 isoform X2

    Conserved Domains (1) summary
    pfam05347
    Location:37 → 95
    Complex1_LYR; Complex 1 protein (LYR family)

  4. XM_011524491.4 → XP_011522793.1  LYR motif-containing protein 9 isoform X1

    Conserved Domains (1) summary
    pfam13232
    Location:37 → 96
    Complex1_LYR_1; Complex1_LYR-like

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    28819756..28834759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315366.1 → XP_054171341.1  LYR motif-containing protein 9 isoform X3

    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8

  2. XM_054315365.1 → XP_054171340.1  LYR motif-containing protein 9 isoform X3

    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8

  3. XM_054315364.1 → XP_054171339.1  LYR motif-containing protein 9 isoform X3

    UniProtKB/Swiss-Prot
    A6NJT7, A8MSI8, Q6X7B8

  4. XM_054315363.1 → XP_054171338.1  LYR motif-containing protein 9 isoform X2

  5. XM_054315362.1 → XP_054171337.1  LYR motif-containing protein 9 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MSI8.2 GenPept UniProtKB/Swiss-Prot:A8MSI8

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