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ZNF584 zinc finger protein 584 [ Homo sapiens (human) ]

Gene ID: 201514, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF584provided by HGNC
Official Full Name
zinc finger protein 584provided by HGNC
Primary source
HGNC:HGNC:27318
See related
Ensembl:ENSG00000171574 AllianceGenome:HGNC:27318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 2.4), skin (RPKM 2.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF584 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58401558..58418327)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61497666..61514284)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58920016..58929694)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15195 Neighboring gene long intergenic non-protein coding RNA 2560 Neighboring gene ZNF584 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58919203-58919848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11082 Neighboring gene zinc finger protein 324B Neighboring gene zinc finger protein 132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58951186-58951696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58952208-58952717 Neighboring gene ZNF132 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Methylomics of breast cancer: Seeking epimarkers in peripheral blood of young subjects. Khakpour G, et al. Tumour Biol, 2017 Mar. PMID 28349825
  2. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
  3. Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis. Li H, et al. Cell Rep, 2022 Dec 20. PMID 36543142
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39899

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 584

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318002.2 → NP_001304931.1  zinc finger protein 584 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and contains an alternate exon the in the 3' coding region that results in a frameshift compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC012313, AK290068, AK298929, BC033149, DB053426, DC350090
    Consensus CDS
    CCDS82414.1
    UniProtKB/TrEMBL
    B4DQS1, F6W0P0
    Related
    ENSP00000320731.7, ENST00000322834.7
    Conserved Domains (2) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    pfam01352
    Location:9 → 48
    KRAB; KRAB box

  2. NM_001363680.1 → NP_001350609.1  zinc finger protein 584 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK290068, BC033149, BX333264, DB062261
    Consensus CDS
    CCDS86814.1
    UniProtKB/TrEMBL
    M0R0A3
    Related
    ENSP00000471105.1, ENST00000593920.5
    Conserved Domains (2) summary
    COG5048
    Location:144 → 329
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_173548.3 → NP_775819.1  zinc finger protein 584 isoform 1

    See identical proteins and their annotated locations for NP_775819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC012313, AK290068, BC033149, DC350090
    Consensus CDS
    CCDS12979.1
    UniProtKB/Swiss-Prot
    A8K203, Q8IVC4
    Related
    ENSP00000306756.3, ENST00000306910.9
    Conserved Domains (6) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    COG5048
    Location:189 → 374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:216 → 236
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214 → 236
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:17 → 56
    KRAB; KRAB box
    pfam13465
    Location:229 → 253
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_134461.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC012313, AK290068, BC017651, BC033149, BM828452, DC350090
    Related
    ENST00000599238.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58401558..58418327
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438392.1 → XP_047294348.1  zinc finger protein 584 isoform X3

  2. XM_047438391.1 → XP_047294347.1  zinc finger protein 584 isoform X1

  3. XM_005258630.6 → XP_005258687.1  zinc finger protein 584 isoform X4

    UniProtKB/TrEMBL
    B4DQS1
    Conserved Domains (2) summary
    smart00349
    Location:17 → 77
    KRAB; krueppel associated box
    pfam01352
    Location:17 → 56
    KRAB; KRAB box

  4. XM_005258628.6 → XP_005258685.1  zinc finger protein 584 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:9 → 69
    KRAB; krueppel associated box
    COG5048
    Location:181 → 366
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:208 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:206 → 228
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:9 → 48
    KRAB; KRAB box
    pfam13465
    Location:221 → 245
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61497666..61514284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320178.1 → XP_054176153.1  zinc finger protein 584 isoform X6

  2. XM_054320176.1 → XP_054176151.1  zinc finger protein 584 isoform X5

  3. XM_054320179.1 → XP_054176154.1  zinc finger protein 584 isoform X4

  4. XM_054320177.1 → XP_054176152.1  zinc finger protein 584 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVC4.1 GenPept UniProtKB/Swiss-Prot:Q8IVC4

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