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Uimc1 ubiquitin interaction motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 20184, updated on 2-Nov-2024

Summary

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Official Symbol
Uimc1provided by MGI
Official Full Name
ubiquitin interaction motif containing 1provided by MGI
Primary source
MGI:MGI:103185
See related
Ensembl:ENSMUSG00000025878 AllianceGenome:MGI:103185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIP110; Rxrip110; 9430016E08Rik; D330018D10Rik; D630032M02Rik
Summary
Enables nuclear retinoid X receptor binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in site of double-strand break. Orthologous to human UIMC1 (ubiquitin interaction motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 8.1), CNS E11.5 (RPKM 7.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Uimc1 in Genome Data Viewer
Location:
13 B1; 13 29.8 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55175693..55248176, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55027880..55100363, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31313 Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene STARR-seq mESC enhancer starr_34599 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1877 Neighboring gene zinc finger protein 346 Neighboring gene STARR-positive B cell enhancer mm9_chr13:55226322-55226622 Neighboring gene predicted gene, 46415 Neighboring gene fibroblast growth factor receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RAP80 is critical in maintaining genomic stability and suppressing tumor development. Yin Z, et al. Cancer Res, 2012 Oct 1. PMID 22896338, Free PMC Article
  2. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. Wu J, et al. J Biol Chem, 2012 Jun 29. PMID 22539352, Free PMC Article
  3. Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Kakarougkas A, et al. Nucleic Acids Res, 2013 Dec. PMID 24013561, Free PMC Article
  4. RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation. Yan J, et al. Biochem Biophys Res Commun, 2007 Oct 12. PMID 17698038, Free PMC Article
  5. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. Yan Z, et al. J Biol Chem, 2002 Aug 30. PMID 12080054

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair.
    Title: DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair.
  2. Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
    Title: Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
  3. Data indicate that RAP80-deficiency promotes genomic instability and causes an increase in cancer risk consistent with the concept that RAP80 exhibits a tumor suppressor function.
    Title: RAP80 is critical in maintaining genomic stability and suppressing tumor development.
  4. a model in which SUMO and Ub modification is coordinated to recruit Rap80 and BRCA1 to DNA damage sites.
    Title: Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates.
  5. Mechanistically, loss of RAP80 suppresses recruitment of the BRCA1-A complex to DNA damage sites and abrogates the DNA damage repair process at DNA damage sites.
    Title: RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.
  6. Both ubiquitin-interacting motif 1(UIM1) and UIM2 of RAP80 recognize an Ile 44-centered hydrophobic patch on ubiquitin but neither UIM interacts with the Lys 63-linked isopeptide bond. [RAP80]
    Title: Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear retinoid X receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
  
part_of BRCA1-A complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BRCA1-A complex subunit RAP80
Names
receptor-associated protein 80
retinoid X receptor interacting protein 110
ubiquitin interaction motif-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293660.1 → NP_001280589.1  BRCA1-A complex subunit RAP80 isoform 2

    See identical proteins and their annotated locations for NP_001280589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK052704, AK160926
    Consensus CDS
    CCDS79189.1
    UniProtKB/TrEMBL
    A0A0R4J183
    Related
    ENSMUSP00000097095.4, ENSMUST00000099496.4
    Conserved Domains (1) summary
    pfam18282
    Location:72 → 122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

  2. NM_001359757.1 → NP_001346686.1  BRCA1-A complex subunit RAP80 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC154610
    Consensus CDS
    CCDS36671.1
    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    A0A0R4J073, E9Q577

  3. NM_001359758.1 → NP_001346687.1  BRCA1-A complex subunit RAP80 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains multiple differences in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC154610

  4. NM_011307.3 → NP_035437.1  BRCA1-A complex subunit RAP80 isoform 1

    See identical proteins and their annotated locations for NP_035437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK052704, AK160926
    Consensus CDS
    CCDS36671.1
    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    A0A0R4J073, E9Q577
    Related
    ENSMUSP00000026997.6, ENSMUST00000026997.12

RNA

  1. NR_121592.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK052704, AK160926
    Related
    ENSMUST00000148702.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55175693..55248176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244499.3 → XP_011242801.1  BRCA1-A complex subunit RAP80 isoform X2

    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    E9Q577
    Conserved Domains (1) summary
    pfam18282
    Location:72 → 128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

  2. XM_030247207.2 → XP_030103067.1  BRCA1-A complex subunit RAP80 isoform X6

    Conserved Domains (1) summary
    pfam18282
    Location:72 → 122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

  3. XM_006517167.4 → XP_006517230.1  BRCA1-A complex subunit RAP80 isoform X1

    UniProtKB/Swiss-Prot
    Q3TU77, Q5U5Q9, Q60811, Q8C3Z8, Q8C719, Q8K1X7
    UniProtKB/TrEMBL
    E9Q577
    Conserved Domains (1) summary
    pfam18282
    Location:72 → 128
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

  4. XM_036157929.1 → XP_036013822.1  BRCA1-A complex subunit RAP80 isoform X4

    Conserved Domains (1) summary
    cd20912
    Location:1 → 22
    AIR_RAP80-like; ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains

  5. XM_036157930.1 → XP_036013823.1  BRCA1-A complex subunit RAP80 isoform X5

  6. XM_036157928.1 → XP_036013821.1  BRCA1-A complex subunit RAP80 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J183
    Conserved Domains (1) summary
    pfam18282
    Location:72 → 122
    RAP80_UIM; RAP80 N-terminal ubiquitin interaction motif

RNA

  1. XR_004937982.1 RNA Sequence

  2. XR_004937981.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U5Q9.2 GenPept UniProtKB/Swiss-Prot:Q5U5Q9

Gene LinkOut

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