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Sart1 squamous cell carcinoma antigen recognized by T cells 1 [ Mus musculus (house mouse) ]

Gene ID: 20227, updated on 2-Nov-2024

Summary

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Official Symbol
Sart1provided by MGI
Official Full Name
squamous cell carcinoma antigen recognized by T cells 1provided by MGI
Primary source
MGI:MGI:1309453
See related
Ensembl:ENSMUSG00000039148 AllianceGenome:MGI:1309453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U5-110K
Summary
Predicted to be involved in mRNA cis splicing, via spliceosome; maturation of 5S rRNA; and positive regulation of cytotoxic T cell differentiation. Predicted to be located in Cajal body; Golgi apparatus; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and catalytic step 2 spliceosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.0), CNS E14 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sart1 in Genome Data Viewer
Location:
19 A; 19 4.31 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5427551..5438731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5377523..5388703, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cystatin E/M Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5366783-5366974 Neighboring gene BAF nuclear assembly factor 1 Neighboring gene eukaryotic translation initiation factor 1A domain containing Neighboring gene RIKEN cDNA D330050I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5389816-5390049 Neighboring gene testis specific 10 interacting protein Neighboring gene RIKEN cDNA 4930481A15 gene Neighboring gene STARR-positive B cell enhancer ABC_E11669 Neighboring gene predicted gene, 54050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Gupta M, et al. Blood, 2000 Jul 15. PMID 10887110
  2. Epitope tagging of proteins at the native chromosomal loci of genes in mice and in cultured vertebrate cells. Chen YI, et al. J Mol Biol, 2006 Aug 18. PMID 16859702
  3. Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Gotoh M, et al. Jpn J Cancer Res, 1998 Aug. PMID 9765622, Free PMC Article
  4. A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Koh MY, et al. Hepatology, 2016 May. PMID 26799785, Free PMC Article
  5. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. Bolland DJ, et al. Gene, 2001 Jun 13. PMID 11410364

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SART1(+/-) mice showed significant up-regulation of HIF-1alpha in circulating and liver-infiltrating immune cells
    Title: A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of 5S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytotoxic T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytotoxic T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U4/U6.U5 tri-snRNP-associated protein 1
Names
SART-1
hypoxia-associated factor
mSART-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016882.3 → NP_058578.3  U4/U6.U5 tri-snRNP-associated protein 1

    See identical proteins and their annotated locations for NP_058578.3

    Status: VALIDATED

    Source sequence(s)
    AB014721, AC122861
    Consensus CDS
    CCDS29460.1
    UniProtKB/Swiss-Prot
    Q8K155, Q9R1I9, Q9R270, Q9Z315
    Related
    ENSMUSP00000047397.5, ENSMUST00000044207.5
    Conserved Domains (1) summary
    pfam03343
    Location:118 → 759
    SART-1; SART-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5427551..5438731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250798.2 → XP_030106658.1  U4/U6.U5 tri-snRNP-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03343
    Location:2 → 601
    SART-1; SART-1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z315.1 GenPept UniProtKB/Swiss-Prot:Q9Z315

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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