TRIM39-RPP21 TRIM39-RPP21 readthrough [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM39-RPP21provided by HGNC
Official Full Name: TRIM39-RPP21 readthroughprovided by HGNC
Primary source: HGNC:HGNC:38845
See related: Ensembl:ENSG00000248167 AllianceGenome:HGNC:38845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRIM39R
Summary: This locus represents naturally occurring read-through transcription between the neighboring TRIM39 (tripartite motif-containing 39) and RPP21 (ribonuclease P/MRP 21kDa subunit) genes on chromosome 6. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
Expression: Ubiquitous expression in testis (RPKM 13.4), ovary (RPKM 7.8) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 6p22.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30329311..30346858)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (30193517..30211069)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30297088..30314635)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM39R, but not TRIM39B, regulates type I interferon response
Title: TRIM39R, but not TRIM39B, regulates type I interferon response.
PKGI interacts with tripartite motif (TRIM) protein TRIM39R. TRIM proteins, through diverse molecular pathways, are often observed to regulate important aspects of cellular homeostasis.
Title: cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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General protein information

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Preferred Names: TRIM39-RPP21 protein

Names: Rpp21 domain-containing TRIM protein; TRIM39-RPP21 read-through transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199119.1 → NP_001186048.1 TRIM39-RPP21 protein

Status: VALIDATED

Source sequence(s)

AL662795, EU012025

UniProtKB/TrEMBL

A0A096LP39, A0A0G2JKY0, A0A140TA46

Related

ENSP00000485378.1, ENST00000623385.3

Conserved Domains (5) summary

cd00021
Location:106 → 143

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam04032
Location:368 → 445

Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

pfam15227
Location:29 → 69

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cl02614
Location:305 → 368

SPRY; SPRY domain

cl19511
Location:136 → 228

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)