CT83 cancer/testis antigen 83 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CT83provided by HGNC
Official Full Name: cancer/testis antigen 83provided by HGNC
Primary source: HGNC:HGNC:33494
See related: Ensembl:ENSG00000204019 MIM:300625; AllianceGenome:HGNC:33494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KKLC1; CXorf61; KK-LC-1
Summary: Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis (RPKM 15.4) See more
Orthologs: all
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Genomic context

Location:: Xq23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (116461686..116462976, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (114871302..114872590, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (115592853..115594137, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six CT83-related Genes-based Prognostic Signature for Lung Adenocarcinoma.
Title: Six CT83-related Genes-based Prognostic Signature for Lung Adenocarcinoma.
Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma.
Title: Cancer-testis antigen KK-LC-1 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma.
Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.
Title: Multiomics analysis reveals CT83 is the most specific gene for triple negative breast cancer and its hypomethylation is oncogenic in breast cancer.
KK-LC-1 may be an effective prognostic biomarker for gastric cancer.
Title: KK-LC-1 may be an effective prognostic biomarker for gastric cancer.
Consequently, KK-LC-1 would be detected at the pre-cancerous condition of the stomach, and may be a useful marker to predict gastric cancer.
Title: Expression of KK-LC-1, a cancer/testis antigen, at non-tumour sites of the stomach carrying a tumour.
We defined the KK-LC-1/presenilin-1/Notch1/Hes1 as a novel signalling pathway that was involved in the growth and metastasis of hepatocellular carcinoma.
Title: Hypomethylation-mediated activation of cancer/testis antigen KK-LC-1 facilitates hepatocellular carcinoma progression through activating the Notch1/Hes1 signalling.
High KK-LC-1 expression was detected in breast cancer, especially in oestrogen receptor-negative subtypes.
Title: Detection of KK-LC-1 Protein, a Cancer/Testis Antigen, in Patients with Breast Cancer.
The KK-LC-1 expression rate was high even in patients with stage I cancer, suggesting that KK-LC-1 is a useful biomarker for early diagnosis of gastric cancer.
Title: Early gastric cancer frequently has high expression of KK-LC-1, a cancer-testis antigen.
KK-LC-1 was frequently expressed in gastric cancer caused by H. pylori infection.
Title: Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer.
CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer.
Title: CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kita-kyushu lung cancer antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.