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NRK Nik related kinase [ Homo sapiens (human) ]

Gene ID: 203447, updated on 17-Mar-2024

Summary

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Official Symbol
NRKprovided by HGNC
Official Full Name
Nik related kinaseprovided by HGNC
Primary source
HGNC:HGNC:25391
See related
Ensembl:ENSG00000123572 MIM:300791; AllianceGenome:HGNC:25391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NESK
Summary
The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
Expression
Biased expression in ovary (RPKM 15.5), placenta (RPKM 15.0) and 8 other tissues See more
Orthologs
mouse all
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Genomic context

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See NRK in Genome Data Viewer
Location:
Xq22.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (105821786..105958610)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (104253759..104390422)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105066532..105202602)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein like 2 Neighboring gene uncharacterized LOC107985680 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104880562-104881086 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104892408-104892914 Neighboring gene uncharacterized LOC105373303 Neighboring gene RNA, U6 small nuclear 207, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:105065433-105066413 Neighboring gene uncharacterized LOC105373304 Neighboring gene HNF1 motif-containing MPRA enhancer 3 Neighboring gene uncharacterized LOC105373305 Neighboring gene serpin family A member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment. Wei T, et al. J Cancer Res Clin Oncol, 2021 Apr. PMID 33387038
  2. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Yanagawa T, et al. Am J Pathol, 2016 Oct. PMID 27634343
  3. Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. Nakano K, et al. Exp Cell Res, 2003 Jul 15. PMID 12837278
  4. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP. Naito S, et al. FEBS Lett, 2020 Jun. PMID 32162334
  5. TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity. Li Z, et al. EMBO Rep, 2020 Jan 7. PMID 31797533, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate.
    Title: Identification and functional activity of Nik related kinase (NRK) in benign hyperplastic prostate.
  2. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
    Title: Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP.
  3. Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment.
    Title: Identification of a novel therapeutic candidate, NRK, in primary cancer-associated fibroblasts of lung adenocarcinoma microenvironment.
  4. The results suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice.
    Title: Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16788, MGC131849, DKFZp686A17109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nik-related protein kinase
NP_940867.2
XP_006724695.1
XP_006724696.1
XP_006724697.1
XP_011529189.1
XP_054182632.1
XP_054182633.1
XP_054182634.1
XP_054182635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021425.2 RefSeqGene

    Range
    4997..141068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198465.4 → NP_940867.2  nik-related protein kinase

    See identical proteins and their annotated locations for NP_940867.2

    Status: REVIEWED

    Source sequence(s)
    BX538345, KF459287, Z68339, Z69734, Z70274, Z83850
    Consensus CDS
    CCDS65305.1
    UniProtKB/Swiss-Prot
    Q32ND6, Q5H9K2, Q6ZMP2, Q7Z2Y5
    Related
    ENSP00000434830.1, ENST00000243300.14
    Conserved Domains (3) summary
    smart00220
    Location:25 → 313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1213 → 1549
    CNH; CNH domain
    cl21453
    Location:18 → 313
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    105821786..105958610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530887.4 → XP_011529189.1  nik-related protein kinase isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:29 → 258
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1158 → 1494
    CNH; CNH domain
    cl21453
    Location:29 → 258
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006724632.4 → XP_006724695.1  nik-related protein kinase isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:25 → 313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1213 → 1541
    CNH; CNH domain
    cl21453
    Location:18 → 313
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006724633.4 → XP_006724696.1  nik-related protein kinase isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:25 → 313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1213 → 1501
    CNH; CNH domain
    cl21453
    Location:18 → 313
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006724634.5 → XP_006724697.1  nik-related protein kinase isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:25 → 313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1213 → 1493
    CNH; CNH domain
    cl21453
    Location:18 → 313
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    104253759..104390422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326660.1 → XP_054182635.1  nik-related protein kinase isoform X3

  2. XM_054326657.1 → XP_054182632.1  nik-related protein kinase isoform X1

  3. XM_054326658.1 → XP_054182633.1  nik-related protein kinase isoform X2

  4. XM_054326659.1 → XP_054182634.1  nik-related protein kinase isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2Y5.2 GenPept UniProtKB/Swiss-Prot:Q7Z2Y5

Gene LinkOut

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