Ostf1 osteoclast stimulating factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ostf1provided by MGI
Official Full Name: osteoclast stimulating factor 1provided by MGI
Primary source: MGI:MGI:700012
See related: Ensembl:ENSMUSG00000024725 AllianceGenome:MGI:700012
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SH3P2; Sh3d3
Summary: Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 31.9), adrenal adult (RPKM 21.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 13.17 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (18557728..18609177, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (18580364..18631813, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SH3P2 suppresses osteoclast differentiation through restricting membrane localization of myosin 1E.
Title: SH3P2 suppresses osteoclast differentiation through restricting membrane localization of myosin 1E.
SH3P2, a novel component of adhesion sites, is involved in Cbl and Src-mediated pathways
Title: SH3P2 in complex with Cbl and Src.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237903

C78236 (e-PCR)
- UniSTS:166132

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: osteoclast-stimulating factor 1

Names: SH3 domain protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017375.3 → NP_059071.1 osteoclast-stimulating factor 1

See identical proteins and their annotated locations for NP_059071.1

Status: VALIDATED

Source sequence(s)

AK002899, AK145949, BY065904

Consensus CDS

CCDS37930.1

UniProtKB/Swiss-Prot

Q3UF05, Q62422

UniProtKB/TrEMBL

A0A494BA97

Related

ENSMUSP00000025631.7, ENSMUST00000025631.7

Conserved Domains (3) summary

cd11772
Location:16 → 68

SH3_OSTF1; Src Homology 3 domain of metazoan osteoclast stimulating factor 1

cd00204
Location:75 → 189

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:76 → 103

ANK; ANK repeat [structural motif]