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St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20440, updated on 28-Oct-2024

Summary

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Official Symbol
St6gal1provided by MGI
Official Full Name
beta galactoside alpha 2,6 sialyltransferase 1provided by MGI
Primary source
MGI:MGI:108470
See related
Ensembl:ENSMUSG00000022885 AllianceGenome:MGI:108470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat1; St6gal; St6galI; St6Gal-I
Summary
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on chromosome 15. [provided by RefSeq, Nov 2011]
Expression
Broad expression in genital fat pad adult (RPKM 48.2), liver E18 (RPKM 29.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See St6gal1 in Genome Data Viewer
Location:
16 B1; 16 14.03 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23043478..23179100)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23224729..23360350)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C730014E05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:23181839-23182022 Neighboring gene predicted pseudogene 6630 Neighboring gene predicted gene 15746 Neighboring gene STARR-positive B cell enhancer ABC_E5533 Neighboring gene cDNA sequence BC106179 Neighboring gene predicted gene, 53940 Neighboring gene STARR-positive B cell enhancer ABC_E1184 Neighboring gene STARR-positive B cell enhancer ABC_E11608 Neighboring gene STARR-positive B cell enhancer ABC_E4161 Neighboring gene predicted gene, 30814 Neighboring gene STARR-seq mESC enhancer starr_40438 Neighboring gene STARR-seq mESC enhancer starr_40440 Neighboring gene STARR-seq mESC enhancer starr_40441 Neighboring gene receptor transporter protein 1 Neighboring gene MBL associated serine protease 1 Neighboring gene STARR-seq mESC enhancer starr_40442 Neighboring gene VISTA enhancer mm1315 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of ST6Gal I-mediated α2,6 sialylation in myoblast proliferation and differentiation. Vergé C, et al. FEBS Open Bio, 2020 Jan. PMID 31622539, Free PMC Article
  2. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Ohmi Y, et al. Nat Commun, 2016 Apr 5. PMID 27046227, Free PMC Article
  3. Inhibiting influenza virus transmission using a broadly acting neuraminidase that targets host sialic acids in the upper respiratory tract. Ortigoza MB, et al. mBio, 2024 Feb 14. PMID 38206008, Free PMC Article
  4. Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. Nasirikenari M, et al. J Leukoc Biol, 2010 Mar. PMID 20007243, Free PMC Article
  5. The Inhibitory Role of α2,6-Sialylation in Adipogenesis. Kaburagi T, et al. J Biol Chem, 2017 Feb 10. PMID 28031460, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
    Title: ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
  2. CCCTC-binding factor: the specific transcription factor of beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
    Title: CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
  3. Platelet-localized ST6Gal1 does not impact IgG sialylation.
    Title: Platelet-localized ST6Gal1 does not impact IgG sialylation.
  4. alpha2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth.
    Title: α2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth.
  5. ST6Gal1 in plasma is dispensable for IgG sialylation.
    Title: ST6Gal1 in plasma is dispensable for IgG sialylation.
  6. Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
    Title: Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
  7. Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
    Title: Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
  8. The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
    Title: The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
  9. Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
    Title: Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
  10. Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.
    Title: Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC116663

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside alpha-2,6-sialyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mononuclear cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation via asparagine ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi medial cisterna IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi trans cisterna IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi trans cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 1
Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
ST6Gal I
alpha 2,6-ST 1
NP_001239434.1
NP_001239435.1
NP_001413535.1
NP_666045.1
XP_006521938.1
XP_006521939.1
XP_011244150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252505.1 → NP_001239434.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_001239434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK034768, BY254258, CD349601, CF741963, CJ238175, CN458528
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000136206.2, ENSMUST00000178797.8
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001252506.1 → NP_001239435.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_001239435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI787561, AK034768, BY134193, CF741963, CJ238175, CN458528
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000110992.2, ENSMUST00000115335.2
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001426606.1 → NP_001413535.1  beta-galactoside alpha-2,6-sialyltransferase 1

    Status: REVIEWED

    Source sequence(s)
    AC163612
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1

  4. NM_145933.4 → NP_666045.1  beta-galactoside alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_666045.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC092222, CF898349, CJ238175
    Consensus CDS
    CCDS28077.1
    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Related
    ENSMUSP00000023601.8, ENSMUST00000023601.14
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    23043478..23179100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521876.5 → XP_006521939.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006521939.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_011245848.2 → XP_011244150.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011244150.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006521875.4 → XP_006521938.1  beta-galactoside alpha-2,6-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006521938.1

    UniProtKB/Swiss-Prot
    Q64685, Q8K1L1
    Conserved Domains (1) summary
    pfam00777
    Location:174 → 379
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64685.2 GenPept UniProtKB/Swiss-Prot:Q64685

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