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St6galnac1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20445, updated on 2-Nov-2024

Summary

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Official Symbol
St6galnac1provided by MGI
Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1provided by MGI
Primary source
MGI:MGI:1341826
See related
Ensembl:ENSMUSG00000009588 AllianceGenome:MGI:1341826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siat7a
Summary
Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in host-mediated regulation of intestinal microbiota composition. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in colon; mammary gland; and salivary gland. Used to study inflammatory bowel disease. Orthologous to human ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 3.7), thymus adult (RPKM 2.2) and 8 other tissues See more
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Genomic context

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See St6galnac1 in Genome Data Viewer
Location:
11 E2; 11 81.49 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116655851..116666333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116765025..116775507, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11735 Neighboring gene cDNA sequence BC018473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene jumonji domain containing 6 Neighboring gene methyltransferase like 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model. Ozaki H, et al. Clin Exp Metastasis, 2012 Mar. PMID 22228572, Free PMC Article
  2. Molecular cloning and genomic analysis of mouse GalNAc alpha2, 6-sialyltransferase (ST6GalNAc I). Kurosawa N, et al. J Biochem, 2000 May. PMID 10788794
  3. Representational difference analysis in a lupus-prone mouse strain results in the identification of an unstable region of the genome on chromosome 11. Fu G, et al. Nucleic Acids Res, 2002 Mar 15. PMID 11884638, Free PMC Article
  4. Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis. Clément M, et al. J Cell Sci, 2004 Oct 1. PMID 15383613
  5. Mucus sialylation determines intestinal host-commensal homeostasis. Yao Y, et al. Cell, 2022 Mar 31. PMID 35303419, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest a role of ST6GalNAc I in promoting the growth and invasion of hepatocarcinoma cells through regulating PI3K/AKT/NF-kappa B signaling, and ST6GalNAc I might be a marker for the prognosis and therapy of hepatocarcinoma.
    Title: Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway.
  2. It was confirmed that MUC1 carries sialyl Tn also in human advanced gastric cancer tissues
    Title: Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.
  3. ST6GalNAc I has a role in O-glycosylation of the integrin beta1 chain and integrin beta 1-mediated signalling
    Title: Expression of sialyl-Tn epitopes on beta1 integrin alters epithelial cell phenotype, proliferation and haptotaxis.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ganglioside biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation by host of symbiont process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Names
SIAT7-A
ST6GalNAc I
ST6GalNAcI
sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A
sialyltransferase 7A
NP_035501.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011371.2 → NP_035501.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

    See identical proteins and their annotated locations for NP_035501.2

    Status: VALIDATED

    Source sequence(s)
    AL645542, BE847090, Y11274
    Consensus CDS
    CCDS36380.1
    UniProtKB/Swiss-Prot
    A2AA23, Q9JJP5, Q9QZ39
    UniProtKB/TrEMBL
    B7ZNQ3
    Related
    ENSMUSP00000009732.8, ENSMUST00000009732.8
    Conserved Domains (2) summary
    pfam00777
    Location:231 → 517
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    pfam05466
    Location:45 → 169
    BASP1; Brain acid soluble protein 1 (BASP1 protein)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116655851..116666333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ39.2 GenPept UniProtKB/Swiss-Prot:Q9QZ39

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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