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St6galnac2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 20446, updated on 2-Nov-2024

Summary

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Official Symbol
St6galnac2provided by MGI
Official Full Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2provided by MGI
Primary source
MGI:MGI:107553
See related
Ensembl:ENSMUSG00000057286 AllianceGenome:MGI:107553
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
II; Siat7; Siat7b; ST6GalNAc
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in protein O-linked glycosylation and protein sialylation. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; lung; and mammary gland. Orthologous to human ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 210.6), kidney adult (RPKM 42.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See St6galnac2 in Genome Data Viewer
Location:
11 E2; 11 81.49 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116567529..116586608, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116676703..116695782, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 16 Neighboring gene small nucleolar RNA, C/D box 1B Neighboring gene small nucleolar RNA, C/D box 1A Neighboring gene STARR-seq mESC enhancer starr_31219 Neighboring gene STARR-seq mESC enhancer starr_31222 Neighboring gene predicted gene 11735 Neighboring gene cDNA sequence BC018473

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins. Platt MD, et al. J Proteome Res, 2009 Mar. PMID 19186949, Free PMC Article
  2. Molecular cloning and genomic analysis of mouse Galbeta1, 3GalNAc-specific GalNAc alpha2,6-sialyltransferase. Kurosawa N, et al. J Biol Chem, 1996 Jun 21. PMID 8662927
  3. Deletion of Vβ3(+)CD4(+) T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8(+) T cells. Ye C, et al. Proc Natl Acad Sci U S A, 2023 Dec 5. PMID 38015847, Free PMC Article
  4. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Takashima S, et al. Biochem Biophys Res Commun, 1999 Jun 24. PMID 10381338
  5. A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Orr SL, et al. Glycobiology, 2013 Mar. PMID 23118208, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sialylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Names
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase
SIAT7-B
ST6GalNAc II
ST6GalNAcII
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II
galNAc alpha-2,6-sialyltransferase II
sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) B
sialyltransferase 7B
NP_033206.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009180.3 → NP_033206.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

    See identical proteins and their annotated locations for NP_033206.2

    Status: PROVISIONAL

    Source sequence(s)
    AK004613
    Consensus CDS
    CCDS36379.1
    UniProtKB/Swiss-Prot
    P70277, Q3UWG0, Q9DC24
    Related
    ENSMUSP00000078501.6, ENSMUST00000079545.6
    Conserved Domains (1) summary
    pfam00777
    Location:110 → 372
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116567529..116586608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_388384.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70277.2 GenPept UniProtKB/Swiss-Prot:P70277

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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