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St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 20449, updated on 2-Nov-2024

Summary

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Official Symbol
St8sia1provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by MGI
Primary source
MGI:MGI:106011
See related
Ensembl:ENSMUSG00000030283 AllianceGenome:MGI:106011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GD3S; Sia-T; Siat8; Siat8a; 9330109E03Rik
Summary
Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Acts upstream of or within cellular response to heat and positive regulation of epithelial cell proliferation. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 5.6), kidney adult (RPKM 5.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See St8sia1 in Genome Data Viewer
Location:
6 G3; 6 74.78 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142767267..142935247, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142821541..142989528, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10416 Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene predicted gene 7457 Neighboring gene STARR-seq mESC enhancer starr_17714 Neighboring gene STARR-seq mESC enhancer starr_17715 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:142866014-142866248 Neighboring gene STARR-seq mESC enhancer starr_17718 Neighboring gene predicted gene 7468 Neighboring gene STARR-seq mESC enhancer starr_17722 Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E2807 Neighboring gene STARR-seq mESC enhancer starr_17724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:143063726-143063909 Neighboring gene predicted gene, 31108 Neighboring gene STARR-seq mESC enhancer starr_17725 Neighboring gene STARR-positive B cell enhancer ABC_E2808 Neighboring gene predicted gene, 38921

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GD3 synthase deletion alters retinal structure and impairs visual function in mice. Abreu CA, et al. J Neurochem, 2021 Aug. PMID 34081777
  2. Different response of the knockout mice lacking b-series gangliosides against botulinum and tetanus toxins. Kitamura M, et al. Biochim Biophys Acta, 2005 Jun 30. PMID 15919183
  3. Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration. Dhanushkodi A, et al. PLoS One, 2011. PMID 22195039, Free PMC Article
  4. Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Akkhawattanangkul Y, et al. Genes Brain Behav, 2017 Jun. PMID 28239983, Free PMC Article
  5. GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation. Handa Y, et al. Pain, 2005 Oct. PMID 16150545

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of biochemical features of ST8 alpha-N-acetyl-neuraminide alpha2,8-sialyltransferase (St8sia) 5 isoforms.
    Title: Analysis of biochemical features of ST8 α-N-acetyl-neuraminide α2,8-sialyltransferase (St8sia) 5 isoforms.
  2. Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
    Title: Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
  3. Knockdown of lncRNA MIR44352HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/betacatenin signaling pathway.
    Title: Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/β‑catenin signaling pathway.
  4. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
    Title: Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
  5. GD3 synthase deletion alters retinal structure and impairs visual function in mice.
    Title: GD3 synthase deletion alters retinal structure and impairs visual function in mice.
  6. Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
    Title: Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
  7. Deletion of GD3 synthase attenuates bone loss that emerges with aging.
    Title: Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging.
  8. Targeted deletion of GD3S protects substantia nigra degeneration and prevents motor deficits associated with MPTP-poisoning.
    Title: Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.
  9. leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice
    Title: Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.
  10. role of GD3 synthase in sciatic nerve and neuronal morphology during peripheral nerve regeneration
    Title: Mice lacking GD3 synthase display morphological abnormalities in the sciatic nerve and neuronal disturbances during peripheral nerve regeneration.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
Names
GD3 synthase
SIAT8-A
ST8Sia I
ST8SiaI
alpha-2, 8-sialyltransferase
alpha-2,8-sialyltransferase 8A
ganglioside GD3 synthase
ganglioside GT3 synthase
sialyltransferase 8 A
sialyltransferase 8A
sialyltransferase St8Sia I
sialytransferase St8Sia I
NP_035504.2
XP_006506991.1
XP_006506992.1
XP_006506993.1
XP_011239876.1
XP_011239877.1
XP_011239878.1
XP_017176961.1
XP_030111143.1
XP_036021874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011374.2 → NP_035504.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

    See identical proteins and their annotated locations for NP_035504.2

    Status: VALIDATED

    Source sequence(s)
    AC122483, BC024821
    Consensus CDS
    CCDS20689.1
    UniProtKB/Swiss-Prot
    Q64687, Q8K1C1
    UniProtKB/TrEMBL
    Q8BWI0
    Related
    ENSMUSP00000032421.4, ENSMUST00000032421.4
    Conserved Domains (1) summary
    pfam00777
    Location:91 → 343
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142767267..142935247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241575.3 → XP_011239877.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_011239877.1

    UniProtKB/TrEMBL
    Q3V3B1, Q64468
    Conserved Domains (1) summary
    pfam00777
    Location:11 → 263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006506929.4 → XP_006506992.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506992.1

    UniProtKB/TrEMBL
    Q3V3B1, Q64468
    Conserved Domains (1) summary
    pfam00777
    Location:11 → 263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006506930.5 → XP_006506993.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506993.1

    UniProtKB/TrEMBL
    Q3V3B1, Q64468
    Conserved Domains (1) summary
    pfam00777
    Location:11 → 263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_017321472.3 → XP_017176961.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:20 → 200
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_030255283.1 → XP_030111143.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:20 → 200
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  6. XM_006506928.4 → XP_006506991.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006506991.1

    UniProtKB/TrEMBL
    Q3V3B1, Q64468
    Conserved Domains (1) summary
    pfam00777
    Location:11 → 263
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  7. XM_011241574.2 → XP_011239876.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

    UniProtKB/TrEMBL
    Q64468
    Conserved Domains (1) summary
    pfam00777
    Location:20 → 272
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  8. XM_011241576.4 → XP_011239878.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:91 → 198
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  9. XM_036165981.1 → XP_036021874.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:91 → 194
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64687.2 GenPept UniProtKB/Swiss-Prot:Q64687

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