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Smr2 submaxillary gland androgen regulated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 20600, updated on 2-Nov-2024

Summary

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Official Symbol
Smr2provided by MGI
Official Full Name
submaxillary gland androgen regulated protein 2provided by MGI
Primary source
MGI:MGI:102762
See related
Ensembl:ENSMUSG00000029281 AllianceGenome:MGI:102762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MSG2; Vcs2
Summary
Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to be located in extracellular region. Orthologous to human SMR3B (submaxillary gland androgen regulated protein 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Smr2 in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88234415..88256912)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88086556..88109053)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene heat shock protein 5 pseudogene Neighboring gene predicted gene 42622 Neighboring gene heat shock protein 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse Vcs2 gene is a composite structure which evolved by gene fusion and encodes five distinct salivary mRNA species. Señorale-Pose M, et al. Gene, 1997 Nov 12. PMID 9409774
  2. Three novel SMR1-related cDNAs characterized in the submaxillary gland of mice show extensive evolutionary divergence in the protein coding region. Tronik-Le Roux D, et al. Gene, 1994 May 16. PMID 8194749
  3. Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. Fu S, et al. FASEB J, 2014 Aug. PMID 24803544, Free PMC Article
  4. Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Erdreich-Epstein A, et al. Genes Chromosomes Cancer, 2006 Feb. PMID 16252261
  5. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Qi L, et al. Cell, 2024 Mar 14. PMID 38442711,

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC130573

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
submaxillary gland androgen regulated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252679.1 → NP_001239608.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate internal exons and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154123, AC163331
    Consensus CDS
    CCDS80321.1
    UniProtKB/Swiss-Prot
    O35979, Q2NKH7
    Related
    ENSMUSP00000143443.2, ENSMUST00000196070.2
    Conserved Domains (1) summary
    pfam15621
    Location:1 → 111
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

  2. NM_001252680.1 → NP_001239609.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239609.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154123, AC163331
    Consensus CDS
    CCDS80321.1
    UniProtKB/Swiss-Prot
    O35979, Q2NKH7
    Conserved Domains (1) summary
    pfam15621
    Location:1 → 111
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

  3. NM_001252681.1 → NP_001239610.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001239610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC154123, AC163331
    Consensus CDS
    CCDS80321.1
    UniProtKB/Swiss-Prot
    O35979, Q2NKH7
    Related
    ENSMUSP00000142688.2, ENSMUST00000196477.5
    Conserved Domains (1) summary
    pfam15621
    Location:1 → 111
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

  4. NM_021289.2 → NP_067264.2  submaxillary gland androgen regulated protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067264.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AC154123, AC163331
    Consensus CDS
    CCDS39137.1
    UniProtKB/Swiss-Prot
    O35985
    Related
    ENSMUSP00000084271.4, ENSMUST00000087043.8
    Conserved Domains (1) summary
    pfam15621
    Location:1 → 111
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    88234415..88256912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254268.1 → XP_030110128.1  submaxillary gland androgen regulated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O09133
    Related
    ENSMUSP00000142444.2, ENSMUST00000199635.5
    Conserved Domains (1) summary
    pfam15621
    Location:1 → 116
    PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09133.1 GenPept UniProtKB/Swiss-Prot:O09133
O35961.1 GenPept UniProtKB/Swiss-Prot:O35961
O35979.1 GenPept UniProtKB/Swiss-Prot:O35979
O35982.1 GenPept UniProtKB/Swiss-Prot:O35982
O35985.1 GenPept UniProtKB/Swiss-Prot:O35985

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