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Sstr2 somatostatin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 20606, updated on 2-Nov-2024

Summary

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Official Symbol
Sstr2provided by MGI
Official Full Name
somatostatin receptor 2provided by MGI
Primary source
MGI:MGI:98328
See related
Ensembl:ENSMUSG00000047904 AllianceGenome:MGI:98328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2
Summary
The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Sstr2 in Genome Data Viewer
Location:
11 E2; 11 79.05 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113510153..113516854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113619327..113626028)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene predicted gene, 42094 Neighboring gene STARR-seq mESC enhancer starr_31085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice. Aerssens J, et al. Gastroenterology, 2007 Apr. PMID 17408648
  2. Somatostatin binds to murine macrophages through two distinct subsets of receptors. Perez J, et al. J Neuroimmunol, 2003 May. PMID 12742651
  3. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. Allen JP, et al. Eur J Neurosci, 2003 May. PMID 12752788
  4. Hepatic somatostatin receptor 2 expression during premalignant stages of hepatocellular carcinoma. Abdel-Hamid NM, et al. Tumour Biol, 2014 Mar. PMID 24163059
  5. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Spier AD, et al. Regul Pept, 2005 Jan 15. PMID 15544857

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sstr2 Defines the Cone Differentiation-Competent Late-Stage Retinal Progenitor Cells in the Developing Mouse Retina.
    Title: Sstr2 Defines the Cone Differentiation-Competent Late-Stage Retinal Progenitor Cells in the Developing Mouse Retina.
  2. sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-beta1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
    Title: sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
  3. Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor.
    Title: Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor.
  4. Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
    Title: Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
  5. A potential role for somatostatin signaling in regulating retinal neurogenesis.
    Title: A potential role for somatostatin signaling in regulating retinal neurogenesis.
  6. Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.
    Title: Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.
  7. SSTR2 is primarily expressed and colocalized intracellularly. Activation of SSTR2, 5 and CB1R protected huntingtin-mutant knock-in striatal neurons from quinolinic-acid-induced toxicity. Co-activation of SSTRs and CB1R resulted in loss of protective effects, delayed ERK1/2 phosphorylation and altered receptor complex composition.
    Title: Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid.
  8. Unpredictable chronic mild stress (UCMS) caused neuroendocrine changes, physical deteriorations, increased anxiety- and depressive-like behaviors and working memory impairments. sst2KO mice displayed behavioral alterations which were similar to stressed WT and exhibited exacerbated changes following UCMS exposure. The evaluations performed in the older mice showed significant long-term effects of UCMS exposure.
    Title: sst(2)-receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing.
  9. SSTR2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of SSTR2 decreases during cyst growth in two polycystic kidney disease mouse models
    Title: The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease.
  10. Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
    Title: Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables somatostatin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucocorticoid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peristalsis IEA
Inferred from Electronic Annotation
more info
  
involved_in peristalsis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
somatostatin receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042606.3 → NP_001036071.1  somatostatin receptor type 2 isoform A

    See identical proteins and their annotated locations for NP_001036071.1

    Status: VALIDATED

    Source sequence(s)
    AL603705
    Consensus CDS
    CCDS59571.1
    UniProtKB/Swiss-Prot
    P30875, P30934, Q91Y73
    Related
    ENSMUSP00000138101.2, ENSMUST00000146390.3
    Conserved Domains (1) summary
    cd15971
    Location:44 → 323
    7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_009217.5 → NP_033243.2  somatostatin receptor type 2 isoform B

    See identical proteins and their annotated locations for NP_033243.2

    Status: VALIDATED

    Source sequence(s)
    AL603705
    Consensus CDS
    CCDS25598.1
    UniProtKB/Swiss-Prot
    P30875
    Related
    ENSMUSP00000102241.2, ENSMUST00000106630.2
    Conserved Domains (1) summary
    cd15971
    Location:44 → 323
    7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    113510153..113516854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30875.1 GenPept UniProtKB/Swiss-Prot:P30875

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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