Tex101 testis expressed 101 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tex101provided by RGD
Full Name: testis expressed 101provided by RGD
Primary source: RGD:621373
See related: EnsemblRapid:ENSRNOG00000020057 AllianceGenome:RGD:621373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tec21
Summary: Involved in positive regulation of leukocyte activation; positive regulation of peptidyl-tyrosine phosphorylation; and positive regulation of release of sequestered calcium ion into cytosol. Located in membrane raft. Is anchored component of membrane. Orthologous to human TEX101 (testis expressed 101). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 320.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89382974..89387340, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80255076..80259442, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81529776..81534149, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in basophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in fertilization	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in regulation of flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal membrane	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: testis-expressed protein 101

Names: lipid raft-associated glycoprotein TEC-21; testis expressed gene 101; testis-expressed sequence 101 protein; testis-expressed sequence 101 protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139037.2 → NP_620606.2 testis-expressed protein 101 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q924B5

UniProtKB/TrEMBL

A6J907, G3V8N9

Related

ENSRNOP00000027202.2, ENSRNOT00000027202.6

Conserved Domains (1) summary

pfam00021
Location:141 → 217

UPAR_LY6; u-PAR/Ly-6 domain