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Hectd1 HECT domain E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 207304, updated on 2-Nov-2024

Summary

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Official Symbol
Hectd1provided by MGI
Official Full Name
HECT domain E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:2384768
See related
Ensembl:ENSMUSG00000035247 AllianceGenome:MGI:2384768
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
opm; b2b327Clo; A630086P08Rik
Summary
Enables ubiquitin protein ligase activity. Involved in neural tube closure. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. Is expressed in several structures, including extraembryonic component; genitourinary system; heart; hemolymphoid system gland; and lung. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 17.4), liver E14 (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hectd1 in Genome Data Viewer
Location:
12 B3; 12 22.11 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (51790504..51876540, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (51743721..51829757, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene striatin, calmodulin binding protein 3 Neighboring gene adaptor-related protein complex AP-4, sigma 1 Neighboring gene STARR-positive B cell enhancer ABC_E5328 Neighboring gene STARR-seq mESC enhancer starr_32110 Neighboring gene predicted gene, 22663 Neighboring gene STARR-positive B cell enhancer ABC_E3051 Neighboring gene predicted gene 5785 Neighboring gene cytochrome c oxidase subunit 7C, mitochondrial pseudogene Neighboring gene predicted gene, 34894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1. Zeng X, et al. ACS Chem Neurosci, 2022 Mar 2. PMID 35148069
  2. Hectd1 is essential for embryogenesis in mice. D'Alonzo D, et al. Gene Expr Patterns, 2019 Dec. PMID 31301385
  3. HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis. Liao S, et al. Arthritis Rheumatol, 2023 Mar. PMID 36121967
  4. circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Fang S, et al. Cell Death Dis, 2018 Mar 14. PMID 29540674, Free PMC Article
  5. Reduced maternal vitamin A status increases the incidence of normal aortic arch variants. Sugrue KF, et al. Genesis, 2019 Jul. PMID 31299141, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis.
    Title: Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis.
  2. HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis.
    Title: HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis.
  3. Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1.
    Title: Vitamin C Inhibits Ubiquitination of Glutamate Transporter 1 (GLT-1) in Astrocytes by Downregulating HECTD1.
  4. Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway.
    Title: Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway.
  5. the expression of Hectd1 was regulated by insulin and by both heat and hypoxia. Our studies reveal that Hectd1 is indispensable for normal embryogenesis and fetal survival.
    Title: Hectd1 is essential for embryogenesis in mice.
  6. SiO2 concomitantly increased circHECTD1 expression, which, in turn, inhibited HECTD1 protein expression.
    Title: circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.
  7. HECTD1 is a novel regulator of retinoic acid signaling required for proper aortic arch development.
    Title: The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch.
  8. HECTD1 may be involved in the regulation of ABCA1-mediated cholesterol export from unloaded macrophages to apoA-I.
    Title: The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages.
  9. Hectd1 regulates the protein level of IQGAP1 through ubiquitination.
    Title: HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.
  10. Hectd1 is required for development of the labyrinthine zone of the mouse placenta.
    Title: Abnormal labyrinthine zone in the Hectd1-null placenta.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Associated conditions

Description Tests
open mind
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12070

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart valve development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spongiotrophoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
HECT domain containing 1
HECT domain-containing protein 1
HECT-type E3 ubiquitin transferase HECTD1
protein open mind
NP_001392110.1
NP_001392111.1
NP_001392112.1
NP_001392113.1
NP_001392114.1
NP_001392115.1
NP_001392116.1
NP_659037.2
XP_011242351.1
XP_011242352.1
XP_036013175.1
XP_036013180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405181.1 → NP_001392110.1  E3 ubiquitin-protein ligase HECTD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  2. NM_001405182.1 → NP_001392111.1  E3 ubiquitin-protein ligase HECTD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  3. NM_001405183.1 → NP_001392112.1  E3 ubiquitin-protein ligase HECTD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  4. NM_001405184.1 → NP_001392113.1  E3 ubiquitin-protein ligase HECTD1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  5. NM_001405185.1 → NP_001392114.1  E3 ubiquitin-protein ligase HECTD1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  6. NM_001405186.1 → NP_001392115.1  E3 ubiquitin-protein ligase HECTD1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  7. NM_001405187.1 → NP_001392116.1  E3 ubiquitin-protein ligase HECTD1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644

  8. NM_144788.3 → NP_659037.2  E3 ubiquitin-protein ligase HECTD1 isoform 1

    See identical proteins and their annotated locations for NP_659037.2

    Status: VALIDATED

    Source sequence(s)
    AC157213, AC159644
    Consensus CDS
    CCDS49064.1
    UniProtKB/Swiss-Prot
    Q69ZR2
    UniProtKB/TrEMBL
    F8WIE5
    Related
    ENSMUSP00000046766.9, ENSMUST00000042052.9
    Conserved Domains (7) summary
    smart00119
    Location:2155 → 2607
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2131 → 2608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    cl23730
    Location:1107 → 1240
    F5_F8_type_C; F5/8 type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    51790504..51876540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157282.1 → XP_036013175.1  E3 ubiquitin-protein ligase HECTD1 isoform X4

    UniProtKB/Swiss-Prot
    Q69ZR2
    Conserved Domains (6) summary
    cd00078
    Location:2083 → 2560
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1276 → 1320
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1106 → 1239
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:1844 → 1917
    BTHB; Basic tilted helix bundle domain

  2. XM_011244049.3 → XP_011242351.1  E3 ubiquitin-protein ligase HECTD1 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZR2
    Conserved Domains (6) summary
    cd00078
    Location:2130 → 2607
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1276 → 1334
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1106 → 1239
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:1891 → 1964
    BTHB; Basic tilted helix bundle domain

  3. XM_036157287.1 → XP_036013180.1  E3 ubiquitin-protein ligase HECTD1 isoform X9

    UniProtKB/Swiss-Prot
    Q69ZR2
    Conserved Domains (5) summary
    cd00078
    Location:2021 → 2498
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_011244050.3 → XP_011242352.1  E3 ubiquitin-protein ligase HECTD1 isoform X2

    UniProtKB/Swiss-Prot
    Q69ZR2
    Conserved Domains (6) summary
    cd00078
    Location:2129 → 2606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam12796
    Location:366 → 457
    Ank_2; Ankyrin repeats (3 copies)
    pfam18410
    Location:1890 → 1963
    BTHB; Basic tilted helix bundle domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZR2.2 GenPept UniProtKB/Swiss-Prot:Q69ZR2

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