U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Csrnp2 cysteine-serine-rich nuclear protein 2 [ Mus musculus (house mouse) ]

Gene ID: 207785, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Csrnp2provided by MGI
Official Full Name
cysteine-serine-rich nuclear protein 2provided by MGI
Primary source
MGI:MGI:2386852
See related
Ensembl:ENSMUSG00000044636 AllianceGenome:MGI:2386852
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csnrp2; CSRNP-2; taip-12
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including cerebral cortex; gonad; hemolymphoid system gland; liver; and lung. Orthologous to human CSRNP2 (cysteine and serine rich nuclear protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 9.8), CNS E18 (RPKM 9.3) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Csrnp2 in Genome Data Viewer
Location:
15 F1; 15 56.32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100377451..100393120, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100479570..100495239, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4149 Neighboring gene RIKEN cDNA 5330439K02 gene Neighboring gene predicted gene 5475 Neighboring gene STARR-positive B cell enhancer mm9_chr15:100274003-100274304 Neighboring gene STARR-seq mESC enhancer starr_39750 Neighboring gene STARR-seq mESC enhancer starr_39751 Neighboring gene LETM1 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_39756 Neighboring gene transcription factor CP2 Neighboring gene STARR-positive B cell enhancer ABC_E7419 Neighboring gene STARR-seq mESC enhancer starr_39757 Neighboring gene STARR-positive B cell enhancer ABC_E4150 Neighboring gene POU domain, class 6, transcription factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC28165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cysteine/serine-rich nuclear protein 2
Names
TGF-beta induced apoptosis protein 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153407.2 → NP_700456.1  cysteine/serine-rich nuclear protein 2

    See identical proteins and their annotated locations for NP_700456.1

    Status: PROVISIONAL

    Source sequence(s)
    AC139571
    Consensus CDS
    CCDS27839.1
    UniProtKB/Swiss-Prot
    Q3UIH1, Q8BGQ2
    Related
    ENSMUSP00000052144.6, ENSMUST00000061457.7
    Conserved Domains (1) summary
    pfam16019
    Location:63 → 278
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100377451..100393120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520683.5 → XP_006520746.1  cysteine/serine-rich nuclear protein 2 isoform X1

    Conserved Domains (1) summary
    pfam16019
    Location:1 → 40
    CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGQ2.1 GenPept UniProtKB/Swiss-Prot:Q8BGQ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools