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ERG ETS transcription factor ERG [ Homo sapiens (human) ]

Gene ID: 2078, updated on 23-Mar-2024

Summary

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Official Symbol
ERGprovided by HGNC
Official Full Name
ETS transcription factor ERGprovided by HGNC
Primary source
HGNC:HGNC:3446
See related
Ensembl:ENSG00000157554 MIM:165080; AllianceGenome:HGNC:3446
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p55; erg-3; LMPHM14
Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Expression
Broad expression in fat (RPKM 7.8), spleen (RPKM 6.9) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
21q22.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (38367261..38661783, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (36750675..37045540, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39739183..40033707, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:39704626-39705825 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62068 Neighboring gene long intergenic non-protein coding RNA 1423 Neighboring gene uncharacterized LOC107985513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:39810939-39811438 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:39820334-39821010 Neighboring gene ERG, ETS transcription factor breakpoint cluster recombination region Neighboring gene Sharpr-MPRA regulatory region 14119 Neighboring gene uncharacterized LOC105372802 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:39879001-39879501 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 13 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:40051342-40052541 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40055463-40056662 Neighboring gene long intergenic non-protein coding RNA 114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18458 Neighboring gene uncharacterized LOC107985480 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:40159061-40160260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. In situ expression of ERG protein in the context of tumor heterogeneity identifies prostate cancer patients with inferior prognosis. Kidd SG, et al. Mol Oncol, 2022 Aug. PMID 35574900, Free PMC Article
  2. The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate Cancer. Khosh Kish E, et al. Int J Mol Sci, 2022 Apr 26. PMID 35563163, Free PMC Article
  3. ERG Expression is Helpful in Differentiating T-Lymphoblastic Lymphoma from Thymoma. Huang W, et al. Int J Surg Pathol, 2023 Apr. PMID 35435050
  4. Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states. Song H, et al. Nat Commun, 2022 Jan 10. PMID 35013146, Free PMC Article
  5. Immunohistochemical expression of the ERG gene in prostatic adenocarcinoma and its relationship with clinicopathological parameters. Birol IE, et al. Malays J Pathol, 2021 Dec. PMID 34958059

See all (478) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4.
    Title: NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4.
  2. ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
    Title: ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia.
  3. ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
    Title: ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
  4. A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.
    Title: A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells.
  5. Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
    Title: Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
  6. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
    Title: Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
  7. Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.
    Title: Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.
  8. ERG Status at the Margin Is Associated With Biochemical Recurrence After Radical Prostatectomy With Positive Surgical Margins.
    Title: ERG Status at the Margin Is Associated With Biochemical Recurrence After Radical Prostatectomy With Positive Surgical Margins.
  9. EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
    Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
  10. Novel high-risk acute myeloid leukemia subgroup with ERG amplification and Biallelic loss of TP53.
    Title: Novel high-risk acute myeloid leukemia subgroup with ERG amplification and Biallelic loss of TP53.
Submit: New GeneRIF Correction See all GeneRIFs (436)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Lymphatic malformation 14
MedGen: CN375813 OMIM: 620602 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.
EBI GWAS Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog
Results of a "GWAS Plus:" General Cognitive Ability Is Substantially Heritable and Massively Polygenic.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcriptional regulator ERG
Names
ERG, ETS transcription factor
FUS/ERG fusion protein
TMPRSS2/ERG fusion
ets-related
transcriptional regulator ERG (transforming protein ERG)
v-ets avian erythroblastosis virus E26 oncogene homolog
v-ets avian erythroblastosis virus E26 oncogene related
v-ets erythroblastosis virus E26 oncogene homolog
v-ets erythroblastosis virus E26 oncogene like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029732.2 RefSeqGene

    Range
    168306..286747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136154.1 → NP_001129626.1  transcriptional regulator ERG isoform 3

    See identical proteins and their annotated locations for NP_001129626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) and variant 5 encode the longest protein (isoform 3).
    Source sequence(s)
    AK297807, AP001422, AP001423, AY204741, BF431907
    Consensus CDS
    CCDS46648.1
    UniProtKB/TrEMBL
    B4DN83
    Related
    ENSP00000414150.2, ENST00000417133.6
    Conserved Domains (2) summary
    cd08540
    Location:134 → 208
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain

  2. NM_001136155.1 → NP_001129627.1  transcriptional regulator ERG isoform 4

    See identical proteins and their annotated locations for NP_001129627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different segment for its 5' UTR and lacks an internal coding segment which results in the use of a downstream start codon, compared to variant 3. The resulting protein (isoform 4) has a shorter N-terminus when it is compared to isoform 3.
    Source sequence(s)
    AK303518, AP001422, AP001423, BF431907, DA850637, DC394344
    Consensus CDS
    CCDS46649.1
    UniProtKB/TrEMBL
    A0A0C4DG41, B4DVX5
    Related
    ENSP00000396268.2, ENST00000453032.6
    Conserved Domains (2) summary
    cd08540
    Location:35 → 109
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:218 → 301
    ETS; erythroblast transformation specific domain

  3. NM_001243428.1 → NP_001230357.1  transcriptional regulator ERG isoform 3

    See identical proteins and their annotated locations for NP_001230357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 3. Variants 3 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AA706319, AK301277, AK309469, AP001422, AP001423, BC040168
    Consensus CDS
    CCDS46648.1
    UniProtKB/TrEMBL
    B4DN83
    Related
    ENSP00000381891.2, ENST00000398919.6
    Conserved Domains (2) summary
    cd08540
    Location:134 → 208
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:317 → 400
    ETS; erythroblast transformation specific domain

  4. NM_001243429.1 → NP_001230358.1  transcriptional regulator ERG isoform 5

    See identical proteins and their annotated locations for NP_001230358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two internal coding exons, compared to variant 3. The resulting protein (isoform 5) is shorter at the N-terminus and lacks an internal segment when it is compared to isoform 3.
    Source sequence(s)
    AA706319, AH001456, AP001422, AP001423, R82102
    Consensus CDS
    CCDS58789.1
    UniProtKB/TrEMBL
    B4DVX5
    Related
    ENSP00000381871.1, ENST00000398897.5
    Conserved Domains (2) summary
    cd08540
    Location:35 → 109
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:194 → 277
    ETS; erythroblast transformation specific domain

  5. NM_001243432.2 → NP_001230361.1  transcriptional regulator ERG isoform 6

    See identical proteins and their annotated locations for NP_001230361.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 3' exon, compared to variant 3. The resulting protein (isoform 6) has a shorter and distinct C-terminus, when it is compared to isoform 3.
    Source sequence(s)
    AY204741, DC356222
    UniProtKB/Swiss-Prot
    P11308
    Conserved Domains (1) summary
    cd08540
    Location:134 → 208
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor

  6. NM_001291391.1 → NP_001278320.1  transcriptional regulator ERG isoform 7

    See identical proteins and their annotated locations for NP_001278320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) ) lacks several exons and its transcription extends past a splice site that is used in variant 3, resulting in a novel 3' coding region and 3' UTR compared to variant 3. The resulting protein (isoform 7) has a shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AY204742, DC356222
    UniProtKB/Swiss-Prot
    P11308
    Related
    ENST00000468474.5
    Conserved Domains (1) summary
    cd08540
    Location:134 → 208
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor

  7. NM_001331025.2 → NP_001317954.1  transcriptional regulator ERG isoform 8

    Status: REVIEWED

    Source sequence(s)
    AA706319, AP001037, AP001422, AP001423, AP001426
    Consensus CDS
    CCDS82674.1
    UniProtKB/TrEMBL
    A8MX39, B5MDW0
    Related
    ENSP00000381877.1, ENST00000398905.5
    Conserved Domains (2) summary
    cd08540
    Location:127 → 201
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:286 → 369
    ETS; erythroblast transformation specific domain

  8. NM_004449.4 → NP_004440.1  transcriptional regulator ERG isoform 2

    See identical proteins and their annotated locations for NP_004440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 3. The resulting protein (isoform 2) is shorter when it is compared to isoform 3.
    Source sequence(s)
    AK297807, AP001422, AP001423, AY204741, BF431907
    Consensus CDS
    CCDS13657.1
    UniProtKB/TrEMBL
    A8MZ24
    Related
    ENSP00000394694.1, ENST00000442448.5
    Conserved Domains (2) summary
    cd08540
    Location:134 → 208
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:293 → 376
    ETS; erythroblast transformation specific domain

  9. NM_182918.4 → NP_891548.1  transcriptional regulator ERG isoform 1

    See identical proteins and their annotated locations for NP_891548.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a different segment for its 5' UTR and 5' coding region, compared to variant 3. The resulting protein (isoform 1) has a shorter and distinct N-terminus when it is compared to isoform 3.
    Source sequence(s)
    AK300395, AP001422, AP001423, BC040168, BF431907, DA850637
    Consensus CDS
    CCDS13658.1
    UniProtKB/Swiss-Prot
    B4DTW5, B4E0T4, P11308, Q16113, Q6XXX4, Q6XXX5, Q8IXK9
    UniProtKB/TrEMBL
    B4DN83
    Related
    ENSP00000288319.7, ENST00000288319.12
    Conserved Domains (2) summary
    cd08540
    Location:127 → 201
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:310 → 393
    ETS; erythroblast transformation specific domain

RNA

  1. NR_111949.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as ERG6) lacks multiple exons and has an alternate 3' exon structure, compared to variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AP001038, AP001426, AY204740, DC356222
    Related
    ENST00000485493.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    38367261..38661783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    36750675..37045540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001243433.1: Suppressed sequence

    Description
    NM_001243433.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11308.3 GenPept UniProtKB/Swiss-Prot:P11308

Gene LinkOut

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